I discussed this on May 18 here:
http://oc1dean.blogspot.com/2012/05/nih-funded-research-provides-new-clues.html
http://www.expatriatehealthcare.com/News/Expatriate_Health_Insurance_News_Potential_treatment_could_prevent_brain_damage_after_strokes683
A compound is being studied by international healthcare
experts at the University of Missouri (MU) and the University of Notre
Dame that could potentially prevent people who have suffered from a
stroke from sustaining brain damage, as well as reduce the amount of
harm the incident causes.
The research, which is outlined in the
journal Molecular Neurodegeneration, involves the analysis of a thiirane
class of gelatinase selective inhibitors and how these function on a
matrix metalloproteinase enzyme (MMP), especially a substance known as
MMP-9, which is known to play a role in a number of important
pathological events that occur following traumatic brain injuries or
similar events.
MU School of Medicine assistant professor of
pathology and anatomical sciences and corresponding author of the
article Zezong Gu said the inhibitors might be combined with a tissue
plasminogen activator to give people who have suffered a stroke a
"longer window of time to receive emergency treatment".
He
pointed out that "time is a matter of life and death" for people who
have had a stroke, echoing the advice of the UK's National Health
Service, which says "immediate medical attention" is needed when a
person begins showing signs of this condition.
"MMPs play a role
in the structure of blood vessels in the brain and are also needed in
the interactions between cells during development and tissue
remodelling," the researcher declared.
Mr Gu stated that without regulation, these enzymes can contribute to stroke.
He
suggested that the gelatinase selective inhibitor could protect the
blood vessels from MMP-9's damaging effects, while preventing damage to
neurons.
In 2005, the scientist had previously played the role of
lead author on a study published in the Journal of Neuroscience that
had revealed MMP-9 could be a promising area that therapeutic medicines
for stroke patients could target.
"We are still in the research phase for this type of compound," Mr Gu declared.
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