Better viability of new neurons is a good thing.
http://www.dovepress.com/articles.php?article_id=10259
Background: Recent studies have
shown that the biological actions and toxicity of the water-soluble
compound, polyhydroxyfullerene (fullerenol), are related to the
concentrations present at a particular site of action. This study
investigated the effects of different concentrations of fullerenol on
cultured rat hippocampal neurons.
Methods and results:
Fullerenol at low concentrations significantly enhanced hippocampal
neuron viability as tested by MTT assay and Hoechst 33342/propidium
iodide double stain detection. At high concentrations, fullerenol
induced apoptosis confirmed by Comet assay and assessment of caspase
proteins.
Conclusion: These findings suggest that
fullerenol promotes cell death and protects against cell damage,
depending on the concentration present. The concentration-dependent
effects of fullerenol were mainly due to its influence on the
reduction-oxidation pathway.
Keywords: fullerenol, nanomaterial, neurotoxicity, neuroprotection, hippocampal neuron
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,112 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Saturday, June 30, 2012
Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability
Labels:
fullerenol,
nano,
neurogenesis,
neuroprotection,
rats
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