This sounds like a useful process for hemorrhages. So get your researcher to explain how they would set up a study for this for stroke.
http://www.dovepress.com/articles.php?article_id=10086
Abstract: Surface modification of
nanocarriers with amphiphilic polymer polyethylene glycol (PEG), known
as PEGylation, is regarded as a major breakthrough in the application of
nanocarriers. However, PEGylated nanocarriers (including liposomes and
polymeric nanoparticles) induce what is referred to as the “accelerated
blood clearance (ABC) phenomenon” upon repeated injection and
consequently they lose their sustained circulation characteristics.
Despite this, the present authors are not aware of any reports of
accelerated clearance due to repeated injection for PEGylated solid
lipid nanoparticles (SLNs), another promising nanocarrier. This study
investigated the pharmacokinetics of PEGylated SLNs upon repeated
administration in mice; moreover, the impact of circulation time on the
induction of the ABC phenomenon was studied in beagles for the first
time. The ABC index, selected as the ratio of the area under the
concentration-time curve from time 0 to the last measured concentration
of a second injection to that of the first injection, was used to
evaluate the extent of this phenomenon. Results showed that the
PEGylated SLNs exhibited accelerated clearance from systemic circulation
upon repeated injection, both in mice and in beagles, and the ratio for
the different time intervals, which showed that the ABC index exhibited
significant difference within 30 minutes following the second
injection, was good enough to evaluate the magnitude of ABC. This ABC
index indicated that the 10 mol% PEG SLNs with a suitable prolonged
circulation time induced the most marked ABC phenomenon in this
research. This study demonstrated that, like PEGylated nanocarriers such
as liposomes and polymeric nanoparticles, PEGylated SLNs induced the
ABC phenomenon upon repeated injection – the beagle was a valuable
experimental animal for this research. Furthermore, the authors
considered that a relatively extended circulation time of the initial
dose may be the underlying major factor determining the induction of the
ABC phenomenon.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,112 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Wednesday, June 13, 2012
Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles
Labels:
beagles,
hemorrhage,
mice,
nanocarriers,
PEGylation
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