http://stroke.ahajournals.org/content/early/2013/02/12/STROKEAHA.111.674507.short
Abstract
Background and Purpose—Despite
the findings that motor imagery and execution are supposed to share
common neural networks, previous studies using
imagery-based rehabilitation have revealed
inconsistent results. In the present study, we investigated whether
feedback of
cortical activities (neurofeedback) using
near-infrared spectroscopy could enhance the efficacy of imagery-based
rehabilitation
in stroke patients.
Methods—Twenty
hemiplegic patients with subcortical stroke received 6 sessions of
mental practice with motor imagery of the distal
upper limb in addition to standard
rehabilitation. Subjects were randomly allocated to REAL and SHAM
groups. In the REAL group,
cortical hemoglobin signals detected by
near-infrared spectroscopy were fed back during imagery. In the SHAM
group, irrelevant
randomized signals were fed back. Upper limb
function was assessed using the finger and arm subscales of the
Fugl-Meyer assessment
and the Action Research Arm Test.
Results—The hand/finger subscale of the Fugl-Meyer assessment showed greater functional gain in the REAL group, with a significant
interaction between time and group (F2,36=15.5; P<0.001).
A significant effect of neurofeedback was revealed even in severely
impaired subjects. Imagery-related cortical activation
in the premotor area was significantly
greater in the REAL group than in the SHAM group (T58=2.4; P<0.05).
Conclusions—Our results suggest that near-infrared spectroscopy–mediated neurofeedback may enhance the efficacy of mental practice with
motor imagery and augment motor recovery in poststroke patients with severe hemiparesis.
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