The readable article link is first then comes the abstract itself. Fascinating finding, which should lead directly to research that determines how to add hamartin to your brain, especially for those of us who already had a stroke.
Ability of brain to protect itself from damage revealed
Abstract:
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3097.html
Previous attempts to identify neuroprotective targets by studying the
ischemic cascade and devising ways to suppress it have failed to
translate to efficacious therapies for acute ischemic stroke1.
We hypothesized that studying the molecular determinants of endogenous
neuroprotection in two well-established paradigms, the resistance of CA3
hippocampal neurons to global ischemia2 and the tolerance conferred by ischemic preconditioning (IPC)3, would reveal new neuroprotective targets. We found that the product of the tuberous sclerosis complex 1 gene (TSC1),
hamartin, is selectively induced by ischemia in hippocampal CA3
neurons. In CA1 neurons, hamartin was unaffected by ischemia but was
upregulated by IPC preceding ischemia, which protects the otherwise
vulnerable CA1 cells. Suppression of hamartin expression with TSC1 shRNA
viral vectors both in vitro and in vivo increased the vulnerability of neurons to cell death following oxygen glucose deprivation (OGD) and ischemia. In vivo,
suppression of TSC1 expression increased locomotor activity and
decreased habituation in a hippocampal-dependent task. Overexpression of
hamartin increased resistance to OGD by inducing productive autophagy
through an mTORC1-dependent mechanism.
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