http://ptjournal.apta.org/content/early/2013/02/20/ptj.20120378.abstract
Abstract
Background Individuals with stroke often sustain increased bone loss and fracture rate. Increasing evidence has demonstrated a link
between cardiovascular health and bone loss in other patient populations.
Objective
To compare the bone density and geometry of the radius diaphysis
between the two sides in people with chronic stroke and
aged-matched controls, and to examine the
relationship between the bone strength index of the hemiparetic radius
diaphysis
and vascular health in people with chronic
stroke.
Design This was a case-control study.
Methods
The radius diaphysis on both sides was scanned using peripheral
quantitative computed tomography in 65 people with chronic
stroke and 34 controls. Large and small artery
elasticity indices were evaluated using a cardiovascular profiling
system.
Results
The paretic radius diaphysis had significantly lower value in cortical
bone mineral density, cortical thickness, cortical
area, bone strength index but greater marrow
cavity area than the non-paretic radius diaphysis in the stroke group
whereas
none of the bone measurements showed significant
side-to-side difference in controls. Multiple regression analyses
showed
that large artery elasticity index and grip
strength remained significantly associated with bone strength index of
the hemiparetic
radius diaphysis, after controlling for age,
sex, time since stroke diagnosis, body mass index, physical activity (R2=0.790, p≤0.001).
Limitations This study was cross-sectional and could not establish causality. The radius diaphysis is not the most common site of fracture
after stroke.
Conclusions
Both the integrity of the vasculature and muscle strength were
significantly associated with the bone strength index at the
hemiparetic radius diaphysis among people with
chronic stroke. The results may be useful in guiding rehabilitative
programs
for enhancing bone health in the paretic arm
following a stroke.
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