Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, April 2, 2013

Vitamin P as a potential molecule for motor neuron diseases

Our stroke researchers should be able to tell us if this new pathway for firing neurons would help us in getting our damaged(but not dead neurons) working again.
Demand your doctor followup with a research project. How else do you think something like this gets done for stroke?
http://saypeople.com/2013/04/02/vitamin-p-as-a-potential-molecule-for-motor-neuron-diseases/#axzz2PL7o32e3

Main Point:

Researchers have found that vitamin-P could help us in the treatment of damaged motor neurons. It can help us in potentiating the new therapeutic strategies for diseases such as Amyotrophic Lateral Sclerosis (ALS).

Journal:

Molecular and Cellular Neuroscience

Study Further:

Vitamin P is also called as 7,8-Dihydroxyflavone. Motor neurons are involved in the control of movements.
Vitamin P works through different path than Brain Derived Neurotrophic Factor (BDNF) that was previously considered important in motor neuron diseases.
Researchers from Ruhr-Universität Bochum have found that vitamin P works by sending the signals through another path than the molecule Brain Derived Neurotrophic Factor (BDNF) that was previously considered as important for the treatment of motor neuron disorders or after spinal cord damage.

“The Brain Derived Neurotrophic Factor only had a limited effect when tested on humans, and even had partially negative consequences”, Prof. Dr. Stefan Wiese from the RUB Work Group for Molecular Cell Biology, said in a statement. “Therefore we are looking for alternative ways to find new approaches for the treatment of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis.”
BDNF stimulates two signaling pathways, the so-called MAP kinase and PI3K/AKT signal paths while researchers found that Vitamin P makes use only of the latter.
Researchers are of the opinion that vitamin P could have less negative effects than BDNF as vitamin P showed only positive effects on the motor neurons in less concentration range.
“These results show how important an accurate determination of dose and effect is”, said Prof. Wiese. “It is easier to use, because vitamin P, in contrast to BDNF, can pass the blood-brain barrier and therefore does not have to be introduced into the cerebrospinal fluid using pumps like BDNF,” Wiese added.
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