No self-prescribing, you do remember the problems when patients used an industrial form of it back in the 80s and 90s.
http://www.ncbi.nlm.nih.gov/pubmed/19096138
Abstract
PURPOSE:
The
objective of this study was to evaluate the neuroprotective potential
of the antioxidant, curcumin compared to alpha-tocopherol in a rat model
of traumatic brain injury (TBI).
METHODS:
Male
Sprague-Dawley rats were administered curcumin (3, 30, 300 mg/kg),
alpha-tocopherol (100 mg/kg), DMSO vehicle, or saline, 30 min prior to
and 30 and 90 min after moderate lateral fluid percussion TBI. Rats were
euthanized at 24 hours after injury and coronal brain sections were
stained with Fluoro-Jade to identify degenerating neurons. Degenerating
neurons in the CA2-3 sector of the dorsal hippocampus were quantified in
10 sections spaced 300 microm apart in each rat.
RESULTS:
One
way ANOVA revealed a significant difference (p = 0.01) between groups.
The curcumin, alpha-tocopherol, and DMSO groups had significantly
reduced numbers of degenerating neurons compared to the saline-treated
group. No significant differences were observed between any of the drug
treatment groups or the DMSO group.
CONCLUSIONS:
Since
protection in the DMSO vehicle group was equal to that of the
experimental groups, no conclusions about neuroprotection regarding
alpha-tocopherol or curcumin can be made from this study. The results
suggest that DMSO may be acting as an overriding neuroprotectant in this
experiment. We conclude that DMSO is a viable neuroprotective agent
against secondary cell death in TBI.
No comments:
Post a Comment