More questions for your doctor on your need to reduce your chances of dementia.
Serum Folate and B12 Levels in Association With Cognitive Impairment Among Seniors
Abstract
Objective: To summarize existing
evidence on the effect of serum folate and vitamin B12 levels on
cognitive impairment among elders
via a meta-analysis, also including unpublished
data from a cross-sectional study of seniors ( > 65 years) residing
in Velestino,
Greece.
Method: Serum measurements and Mini-Mental State Examination (MMSE) assessments were available for 593 Velestinians. In addition,
12 studies availing data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were identified following a search algorithm; pooled effect estimates were derived.
Results:
Cognitive impairment (MMSE < 24) among Velestenians was associated
with lower education level in both genders; decreased
social activity, depressive symptoms and low folate
levels in males; older age in females. Meta-analyses showed an adverse
effect of low-folate levels on cognition (OR: 1.66,
95% CI: 1.40-1.96); B12 was nonsignificantly associated (OR: 1.11, 95%
CI: 0.88-1.40).
Discussion: Low folate levels are associated with cognitive impairment of seniors; underlying pathophysiological mechanisms should be
further explored.
No comments:
Post a Comment