Do you really think your doctor subscribes to the journal, Gut? What did they learn from this knowledge? Any way to reduce stroke risk?
http://www.sciencedaily.com/releases/2013/01/130109080825.htm
A new study by NYU School of Medicine researchers reveals that an especially virulent strain of the gut bacterium Helicobacter pylori (H. pylori)
isn't implicated in the overall death rate of the U.S. population, and
may even protect against stroke and some cancers. The findings, based a
nationwide health survey of nearly 10,000 individuals over a period of
some 12 years, are published online, January 9, in the journal Gut.
Those individuals carrying the most virulent strain of H. pylori,
the study found, had a 55 percent reduced risk of deaths from stroke
compared with their counterparts who were not infected with H. pylori. Participants with the most virulent strain also had a 45 percent reduced risk of death from lung cancer.
These surprising findings emerged from an analysis by Yu Chen, PhD,
MPH, associate professor of population health and environmental
medicine, and Martin J. Blaser, MD, professor of internal medicine and
professor of microbiology, of individuals who participated in a national
survey designed to assess the health and nutritional status of adults
and children in the United States. Previous studies by Dr. Blaser have
confirmed the bacterium's link to gastric diseases ranging from
gastritis to stomach cancer. He and Dr. Chen have more recently shown
that H. pylori may protect against childhood asthma. The most virulent H. pylori strains have a gene called cagA.
"The significance of this study is that this is a prospective cohort
of participants representative of the U.S. population with a long
follow-up," says Dr. Chen. "We studied both the overall H. pylori as
well as cagA strain of H. pylori, which is more interactive with the human body. We found that H. pylori is not related to the risk of death from all causes, despite it being related to increased risk of death from gastric cancer."
"This finding confirms earlier work, however, that gastric cancers
are now uncommon in the United States," says Dr. Chen. "We also found
that H. pylori was related to a reduced risk of stroke and lung cancer, and these effects were stronger for the cagA strain, suggesting its mixed role in human health," she says.
H. pylori, an ancient bacterium, lives in the mucous layer
lining the stomach where, until recently, it survived for decades. More
than half of the world's population harbor H. pylori in their
upper gastrointestinal tract. Mainly transmitted in families, the
bacterium is usually acquired before age 10. In developing countries H. pylori is still prevalent, but is vanishing in the developed world thanks to better sanitation and widespread use of antibiotics.
To better understand the relationship between H. pylori and
the overall death rate, or all-cause mortality, the researchers analyzed
data from 9,895 participants in the National Health and Nutrition
Surveys (NHANES III), enrolled from 1988 to 1994. Test results for H.
pylori and cagA were available on 7,384 subjects at the time of enrollment, and participants were followed until 2000.
There was no association of either H. pylori-positivity or cagA-positivity with all-cause mortality in the population, the researchers found. Participants with and without H. pylori experienced a similar risk of death from all causes. Consistent with past reports, a strong association was observed between H. pylori and gastric cancer mortality, according to the study. Individuals who were H. pylori positive were 40 times more likely to die from gastric cancer. The study also found that participants with cagA-positivity had a 55 percent reduced risk of deaths from stroke compared with their counterparts who were H. pylori negative/ cagA-negative. Participants with cagA-positivity also had a 45 percent reduced risk of deaths from lung cancer.
"The most interesting finding was that there is a strong inverse
association with stroke which could be protective," says Dr. Blaser.
"There is some precedent for this and it is possible that the same cells
(T reg cells) that H. pylori induces that protect against childhood asthma could be the protective agents, however, the findings need to be confirmed."
No comments:
Post a Comment