What is your doctor going to learn from this to create a stroke protocol to generate new neurons in your brain?
http://www.frontiersin.org/Journal/abstract/72191
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1Neuroscience Institute Cavalieri Ottolenghi (NICO),
University of Turin,
Italy
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2
Dept. of Life Sciences and Systems Biology,
Italy
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3
Dept. of Veterinary Sciences,
Italy
Two decades of investigation on adult
neurogenesis yielded an utterly new vision of brain plasticity in
mammals. Nevertheless, the ultimate goal of exploiting neurogenic
processes for brain repair is still far from being achieved. Starting
from this antinomy, the big question is: should be the research field of
adult neurogenesis considered as a dead end in the perspective of brain
repair, or, alternatively, do we need further efforts directed to
better understand this biological process in order to solve the problem?
Though neurobiologists do not share the same answer,
it is evident that
the huge knowledge gathered up to now in the field is not sufficient
for granting translation of basic neurobiological research to reparative
strategies. In this opinion article we suggest that failure in
developing efficacious therapeutic approaches is linked to several
unresolved issues in both domains of physiological and lesion-induced
neurogenesis. We focus on the role of some aspects (e.g.,
stem/progenitor cell availability, regenerative capacity, glial cell
activation, inflammatory reactions) which can determine the potential
for neurogenic plasticity, yet depending on different variables which
influence the tissue environment (ages, anatomical regions,
homeostatic/pathologic states) and in turn depend on evolutionary
constraints linked to the animal species. In our opinion, further
investment/investigation directed at filling such existing gaps of
knowledge in brain plasticity are needed before a new era for brain
repair might be opened.
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