Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, April 7, 2015

Erythropoietin Promotes Neural Plasticity and Spatial Memory Recovery in Fimbria-Fornix–Lesioned Rats

How soon is your doctor following up with this in human clinical trials?
http://nnr.sagepub.com/content/early/2015/04/04/1545968315572389.abstract?

  1. William Almaguer-Melian, PhD1
  2. Daymara Mercerón-Martínez, MSc2
  3. Nancy Pavón-Fuentes, PhD1
  4. Esteban Alberti-Amador, PhD1
  5. Rilda Leon-Martinez1
  6. Nuris Ledón, PhD3
  7. Susana Delgado Ocaña4
  8. Jorge A. Bergado Rosado, PhD1
  1. 1Centro Internacional de Restauración Neurológica, La Habana, Cuba
  2. 2Centro de Neurociencias de Cuba, La Habana, Cuba
  3. 3Centro de Inmunología Molecular, La Habana, Cuba
  4. 4Universidad de La Habana, La Habana, Cuba
  1. Jorge A. Bergado Rosado, Centro Internacional de Restauración Neurológica, Ave 25, No. 15805, Playa 11300, La Habana, Cuba. Email: bergado@neuro.ciren.cu

Abstract

Background. Erythropoietin (EPO) upregulates the mitogen activated protein kinase (MAPK) cascade, a central signaling pathway in cellular plastic mechanisms, and is critical for normal brain development. Objective. We hypothesized that EPO could modulate the plasticity mechanisms supporting spatial memory recovery in fimbria-fornix–transected animals. Methods. Fimbria-fornix was transected in 3 groups of rats. Seven days later, EPO was injected daily for 4 consecutive days within 10 minutes after training on a water maze task. Results. Our results show that EPO injections 10 minutes after training produced a substantial spatial memory recovery in fimbria-fornix–lesioned animals. In contrast, an EPO injection shortly after fimbria-fornix lesion surgery does not promote spatial-memory recovery. Neither does daily EPO injection 5 hours after the water maze performance. EPO, on the other hand, induced the expression of plasticity-related genes like arc and bdnf, but this effect was independent of training or lesion. Conclusions. This finding supports our working hypothesis that EPO can modulate transient neuroplastic mechanisms triggered by training in lesioned animals. Consequently, we propose that EPO administration can be a useful trophic factor to promote neural restoration when given in combination with training.
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