Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, October 3, 2015

Rebuilding brain circuitry with living micro-tissue engineered neural networks

It mentions long distance axonal connections. This is something I could have greatly used since I assume that a huge chunk of my white matter underlying my dead premotor and motor cortex also is dead and there is miles of neuronal connections I need to replace. If we had anything even close to an objective damage diagnosis my doctors would know exactly what was damaged and how to initiate fixes to those problems. But that won't occur until we get rid of the deadwood in the current stroke leadership.
http://online.liebertpub.com/doi/abs/10.1089/ten.TEA.2014.0557?journalCode=tea

To cite this article:
Miss Laura A. Struzyna, Dr. John A. Wolf, Miss Constance J. Mietus, Mr. Dayo Olaolu Adewole, Dr. H. Isaac Chen, Dr. Douglas Smith, and Dr. D. Kacy Cullen. Tissue Engineering Part A. -Not available-, ahead of print. doi:10.1089/ten.TEA.2014.0557.
Online Ahead of Editing: September 28, 2015

Author information

Miss Laura A. Struzyna
University of Pennsylvania, Bioengineering, Philadelphia, Pennsylvania, United States
;
University of Pennsylvania, Neurosurgery, Philadelphia, Pennsylvania, United States
;
Philadelphia Veterans Affairs Medical Center, Phladelphia, Pennsylvania, United States;
Dr. John A. Wolf
University of Pennsylvania, Neurosurgery, Philadelphia, Pennsylvania, United States
;
Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States;
Miss Constance J. Mietus
University of Pennsylvania, Neurosurgery, Philadelphia, Pennsylvania, United States;
Mr. Dayo Olaolu Adewole
University of Pennsylvania, Bioengineering, Philadelphia, Pennsylvania, United States
;
University of Pennsylvania, Neurosurgery, Philadelphia, Pennsylvania, United States
;
Philadelphia Veterans Affairs Medical Center, Phladelphia, Pennsylvania, United States;
Dr. H. Isaac Chen
University of Pennsylvania, Neurosurgery, Philadelphia, Pennsylvania, United States
;
Philadelphia Veterans Affairs Medical Center, Phladelphia, Pennsylvania, United States;
Dr. Douglas Smith
University of Pennsylvania, Neurosurgery, Philadelphia, Pennsylvania, United States;
Dr. D. Kacy Cullen, PhD
University of Pennsylvania, Neurosurgery, Philadelphia, Pennsylvania, United States
;
Philadelphia Veterans Affairs Medical Center, Phladelphia, Pennsylvania, United States;
Accepted: 09 22 2014
Received: 09 22 2014

ABSTRACT

Prominent neuropathology following trauma, stroke and various neurodegenerative diseases includes neuronal degeneration as well as loss of long-distance axonal connections. While cell replacement and axonal pathfinding strategies are often explored independently, there is no strategy capable of simultaneously replacing lost neurons and re-establishing long-distance axonal connections in the central nervous system. Accordingly, we have created micro-tissue engineered neural networks (micro-TENNs) which are preformed constructs consisting of long integrated axonal tracts spanning discrete neuronal populations. These living micro-TENNs reconstitute the architecture of long-distance axonal tracts, and thus may serve as an effective substrate for targeted neurosurgical reconstruction of damaged pathways in the brain. Cerebral cortical neurons or dorsal root ganglia neurons were precisely delivered into the tubular constructs, and properties of the hydrogel exterior and extracellular matrix internal column (250 - 500 μm diameter) were optimized for robust neuronal survival and to promote axonal extensions across the 2.0 cm tube length. The very small diameter permits minimally invasive delivery into the brain. Here, pre-formed micro-TENNs were stereotaxically injected into naïve rats to bridge deep thalamic structures with the cerebral cortex in order to assess construct survival and integration. We found that micro-TENN neurons survived at least one month and maintained their long axonal architecture along the cortical-thalamic axis. Notably, we also found neurite penetration from micro-TENN neurons into the host cortex, with evidence of synapse formation. These micro-TENNs represent a new strategy to facilitate nervous system repair by recapitulating features of neural pathways to restore or modulate damaged brain circuitry.
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