Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, November 21, 2015

Stroke Rounds: Post-Acute Peptide Tx Reduces Disability

How many decades is this going to take before it becomes a standard stroke protocol? After further good test results? Unless YOU start screaming at your doctors and hospital this won't occur for 50 years. It is all up to YOU, since we have no great stroke association taking care of these simple tasks. Any clinical study using the Rankin scale to measure results is deceiving themselves that it is a valid measurement tool. There is nothing objective about it, except 6 - dead. This is something a great stroke association would be doing, training clinical researchers in how to properly run research trials.
http://www.medpagetoday.com/Cardiology/Strokes/54821?xid=nl_mpt_cardiodaily_2015-11-20&eun=gd3r
Injections of the product sold as Cerebrolysin in Russia, China, and surrounding countries had a "large" effect size on the Action Research Arm Test (ARAT) score on day 90 compared with placebo (Mann-Whitney estimator 0.71, P<0.0001).


"The multivariate effect size on global status, as assessed using 12 different outcome scales, indicated a small-to-medium superiority of Cerebrolysin, (Mann-Whitney estimator 0.62; 95% CI 0.58-0.65; P<0.0001)," Dafin F. Muresanu, PhD, of "Iuliu Hatieganu" University of Medicine and Pharmacy in Napoca, Romania, and colleagues found.
The proportion of patients with minimal disability at 90 days, marked by a modified Rankin Scale (mRS) score of 0 to 1, was 42.3% with the injections compared with 14.9% on placebo, the researchers reported online in Stroke.
The intervention likewise up-shifted the proportion of patients with a "good" functional outcome marked by mRS scores of 2 or less.
Cerebrolysin is a mixture of low molecular weight neuropeptides and free amino acids derived from pig brain tissue through a standardized manufacturing process.
"No one knows exactly what's in there, nevertheless it has a very strong track record in animal models," commented Costantino Iadecola, MD, director of Cornell's Brain and Mind Research Institute in New York City.
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The findings were promising as there's little other than rehabilitation to offer patients in the post-acute phase, he said. "Many of the drugs we have were originally developed from biological material and we had to use molecular biology to develop recombinant forms and control adverse effects."
But he warned against trying to import the substance, as one Alzheimer's group has noted can be done.
"Before the I's are dotted and the T's are crossed, don't rush into treatment," Iadecola cautioned, noting that the small studies done so far are not enough to establish safety in terms of antibody development and even possibly prion diseases, which could take years to show up.
The CARS trial randomized 208 moderate-to-severe stroke patients to double-blind treatment with Cerebrolysin (once-daily 30 mL injections) or saline placebo for 21 days, starting 24 to 72 hours after onset, along with a standardized rehabilitation program for all patients.
Baseline stroke severity, disability, and other characteristics were similar between groups.
"Cerebrolysin was safe and well tolerated," the researchers noted, pointing to a 3.8% rate of premature discontinuation.
"This study was planned as an exploratory phase II trial," Muresanu's group wrote. "This design limits the degree of evidence obtained; thus, the results should be confirmed in a large-scale phase III trial. In addition, the generalizability of our results to other regions and stroke populations should be evaluated in future research."
The study was funded by EVER Neuro Pharma.
Muresanu disclosed relationships with EVER Neuro Pharma.
Iadecola disclosed having no relevant relationships with industry.

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