Interesting premise that we are not challenging our 'thermal comfort zone' and thus more likely to develop cardiovascular disease. In mice at least.
I can just see shivering patients in the hospital being told that cold is good for your vascular system.
http://www.biosciencetechnology.com/news/2015/11/warm-temperatures-worsen-cardiovascular-disease-not-diabetes-risk?
You might want to think twice before turning up that thermostat
during the holidays. A new study led by UCSF researchers has found that
mice who spend too much time in their thermal “comfort zone” while
gorging on fatty foods more than double their risk of developing
cardiovascular disease compared to mice who stayed cool while eating the
same diet.
The findings suggest that the standard practice of housing mice at
relatively cool temperatures may actually benefit the animals’ long-term
health by keeping their metabolisms active. On the other hand, it could
be an impediment for researchers trying to understand metabolic disease
in humans, since we spend much of our time at carefully regulated
“thermoneutrality” – the temperature at which our metabolisms don’t have
to do any extra work to keep us warm.
“This has had a profound effect on how I look at results coming out
of my own lab,” said study senior author Ajay Chawla, M.D., Ph.D., a
professor at UCSF’s Cardiovascular Research Institute and the
departments of physiology and medicine in UCSF’s School of Medicine. “I
don’t believe anything until we do it again at thermoneutrality.”
There is ongoing debate in the research community about the best
temperature for the health and comfort of laboratory mice. The National
Research Council recommends housing mice between 20 and 26 degrees
Celsius (68 to 79 degrees Fahrenheit), well below the animals’
thermoneutral zone, which is closer to 30 C (86 F).
Chawla, who studies the effects of cold on metabolism, became
interested in whether the practice of housing mice at relatively chilly
temperatures changed their risk of developing metabolic disease.
Nearly two decades of research show that diets high in LDL
cholesterol trigger chronic vascular inflammation, aggravating the
growth of atherosclerotic plaques and leading to heart disease. In
recent years, studies have suggested heightened immune activity could
also be responsible for the onset of insulin resistance, an early
warning sign of diabetes.
In the new paper, published Nov 5 in the journal Cell Metabolism,
Chawla’s team found that mice housed at 30 C and fed fatty diets
developed inflammation much more rapidly and ended up with twice as many
atherosclerotic plaques than those housed at the more typical 22 C. On
the other hand, the heightened inflammation resulting from warmer
housing conditions had no significant effect on insulin resistance, in
sharp contrast with previous results linking the two.
“This was a big surprise,” Chawla said. “It could be that inflammation has less to do with diabetes than we thought.”
Chawla suspects that the chronic chill lab mice typically experience
protects against chronic inflammation by constantly revving the
metabolism to produce heat. The heart rate of a mouse at 22 C is
typically twice as high as a mouse at 30 C, they expend twice as much
energy at rest, and have significantly elevated blood pressure.
“The magnitude of the response is huge,” Chawla said. “We do all
these studies on mice hoping to apply what we learn about mouse
physiology to humans, but it’s like we’ve been studying humans on
speed.”
Source: University of California San Francisco
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My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
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