Deans' stroke musings: Molecular regulation of dendritic spine dynamics and their potential impact on synaptic plasticity and neurological diseases

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, November 14, 2015

Molecular regulation of dendritic spine dynamics and their potential impact on synaptic plasticity and neurological diseases

Your doctor needs to know how to encourage dendritic branching for your recovery so start SCREAMING at her/him for answers. You shouldn't have to diagnose and treat yourself. They are being paid the big bucks.
http://www.sciencedirect.com/science/article/pii/S0149763415301068

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doi:10.1016/j.neubiorev.2015.09.020

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Highlights

•: Basic understanding and recent advances of molecular signaling mechanism involved in dendritic spines dynamics.
•: Mechanistic details of the dendritic spine anomalies, and their potential impact on psychiatric disorders and neurological diseases.
•: Different strategies to restore the dendritic spines structure-functions in brain diseases.

Abstract

The structure and dynamics of dendritic spines reflects the strength of synapses, which are severely affected in different brain diseases. Therefore, understanding the ultra-structure, molecular signaling mechanism(s) regulating dendritic spine dynamics is crucial. Although, since last century, dynamics of spine have been explored by several investigators in different neurological diseases, but despite countless efforts, a comprehensive understanding of the fundamental etiology and molecular signaling pathways involved in spine pathology is lacking. The purpose of this review is to provide a contextual framework of our current understanding of the molecular mechanisms of dendritic spine signaling, as well as their potential impact on different neurodegenerative and psychiatric diseases, as a format for highlighting some commonalities in function, as well as providing a format for new insights and perspectives into this critical area of research. Additionally, the potential strategies to restore spine structure-function in different diseases are also pointed out. Overall, these informations should help researchers to design new drugs to restore the structure-function of dendritic spine, a “hot site” of synaptic plasticity.