Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, June 2, 2016

Stem cell brain injections let people walk again after stroke

Nothing here gives me any sense of hope that stem cells work. They have NO fucking clue if the stem cells even survived and migrated to the correct locations. 
1. No reference to how many growth factors were created. 
2. Nothing on the objective damage in the brain.  
3. No specification of what scale was used for measurement so we could tell how objective it was. 
4. Nothing listed here proves cause and effect.
I really do wonder if our researchers even know how to run research.
Maybe the real cause of the improvement was the trepanation.
Healed over trepanation, notice the rounded edges

https://www.newscientist.com/article/2091841-stem-cell-brain-injections-let-people-walk-again-after-stroke
People once dependent on wheelchairs after having a stroke are walking again since receiving injections of stem cells into their brains. Participants in the small trial also saw improvements in their speech and arm movements.
“One 71-year-old woman could only move her left thumb at the start of the trial,” says Gary Steinberg, a neurosurgeon at Stanford University who performed the procedure on some of the 18 participants. “She can now walk and lift her arm above her head.”
Run by SanBio of Mountain View, California, this trial is the second to test whether stem cell injections into patients’ brains can help ease disabilities resulting from stroke. Patients in the first, carried out by UK company ReNeuron, also showed measurable reductions in disability a year after receiving their injections and beyond.
All patients in the latest trial showed improvements. Their scores on a 100-point scale for evaluating mobility – with 100 being completely mobile – improved on average by 11.4 points, a margin considered to be clinically meaningful for patients. “The most dramatic improvements were in strength, coordination, ability to walk, the ability to use hands and the ability to communicate, especially in those whose speech had been damaged by the stroke,” says Steinberg.

..
In both trials, improvements in patients’ mobility had plateaued since having had strokes between six months and three years previously.
“We used to think the affected brain circuits were dead,” says Steinberg. “Now, we have to rethink this, and I personally think the circuits are inhibited, and our treatment helps to disinhibit them.”

Baby steps

Steinberg injected the cells through a borehole in the skull into regions of the brain that control motor movements, and which had been damaged by the stroke. Each participant received either 2.5, 5 or 10 million cells.
The injected material consisted of mesenchymal stem cells taken from the bone marrow of two healthy donors. SanBio genetically engineered the cells to possess a gene called Notch1, which activates factors that help brain development in infants. Experiments in rats revealed that the engineered stem cells disappear within a month or so, but not before secreting several growth factors that build connections between brain cells and spawn the growth of new blood vessels to nourish growing brain tissue.
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“We think the cells change the adult brain so that it’s more like a baby’s brain, which repairs very well,” says Steinberg. “They are secreting all sorts of growth factors, which aid repair, and which also alter the immune system to get rid of inflammation that otherwise obstructs repair.”
In the ReNeuron trial, patients received neural stem cells originally extracted from the brains of aborted fetuses, then multiplied to produce larger amounts.
“This is very encouraging news for the field of stem cell research and especially patients with established disability as a result of stroke, where this is no proven treatment to aid recovery,” says Julian Howell, chief medical officer at ReNeuron. “Both companies are at a similar stage of development, and while it’s great to hear stories of major improvements in some patients, controlled studies are absolutely necessary to establish the benefits and risks of stem cell therapy for stroke.”

Remarkable results

ReNeuron is preparing a second trial, while SanBio is in the process of performing the treatment on a further 156 patients. Steinberg says that this time, a third of the patients will receive a sham treatment – a hole in the head without the injection of stem cells – and the remainder will receive either 2.5 or 5-million cells.
There are around 30 similar trials in progress. These deliver stem cells to stroke patients by injecting them into the blood, but none have shown such remarkable results as the two trials that injected the cells into the brain, says Steinberg. “We still have much to learn, including the right cell for the job, the right dose and the right means of delivery,” he says.
The UK Stroke Association welcomed the results but also cautioned that further trials are essential to provide additional evidence the treatment works. “Although small, this latest trial suggests that the treatment is safe and may be able to restore movement to people previously lost after stroke,” says Shamim Quadir, a spokesman for the association. “The trial adds to a growing body of early clinical evidence suggesting stem cell treatment could promote recovery in people months, even years, after having a stroke, bringing hope to many living with a disability.”
Journal reference: Stroke, in press

1 comment:

  1. I had stem cell therapy in Peru. Yes, Dean, I am sure your scam antennae went up then.It cost $25000US and with our poor exchange rate at the time, along with airfare and accommodation, cost me $42,000au. If I had done it two years earlier, it might have only cost me $25000au total.
    I do not see any great recovery in the areas that I wanted recovery (fatigue, memory, emotional response) but it has slightly improved the movement in my affected arm, in that it is easier to manoeuvrer in a tight situation. I still cannot give a decent hand shake response, but I do not have to use my good arm to move my dud arm when lying in bed. Was it worth the money I paid? Probably not, but my Dad had just died, so I used my inheritance money.

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