Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, June 2, 2016

Hormone causes decline in cognition after social stress

Your social stress is going to go thru the roof post-stroke after you lose most, if not all of your friends. What the hell is your doctor doing to combat that stress? I bet nothing, especially since nothing was done to stop the neuronal cascade of death.

Hormone causes decline in cognition after social stress

How does stress influence our cognitive performance? This is an issue scientists at the Max Planck Institute of Psychiatry in Munich have been dealing with. For the first time, they have identified a brain mechanism that explains why the cognitive performance of mice is reduced after being exposed to social stress. This finding will help to improve our understanding and treatment of disorders involving cognitive decline in humans.

The is a brain region responsible for mental activity, perception and recognition, in short for cognition. No matter whether we want to respond flexibly to certain situations, have to do several things simultaneously or make plans for the future – none of this would be possible without our prefrontal cortex. However, these processes are very susceptible to stress. Our anger resulting from being stuck in a traffic jam in the morning or trouble with the boss at lunchtime causes social stress. The so-called Corticotropin-releasing factor (CRF) controls our reaction in the prefrontal cortex; however, which exact role it plays was not clear previously.
Therefore, scientists at the Max Planck Institute of Psychiatry tested what exactly happens in the brain during such stressful periods in mice. They exposed mice to acute and observed a in the rodents some hours later. The mice were not able to show in a test maze or remember the chronological sequence of events they had learned before.
In order to find out more about the role CRF plays in this process, the scientists blocked the action of the peptide using a drug, a so-called CRF antagonist. This time, the performance of the mice did not decrease several hours after the stressful event; they were able to perform the required tasks as successfully as they had done without stress.
"The crucial point is that we were able to identify the mechanism responsible for the reduction in performance after stress," Mathias Schmidt, research group leader and head of the study, summarizes. Understanding this mechanism is important in order to comprehend how stress affects our thinking, feeling and perceiving. Since the mechanisms underlying the flexibility in perception and memory performance are similar in and humans, it is very probable that the findings are transferable to humans. Many psychiatric diseases such as depression or schizophrenia are accompanied by impaired cognitive function. With their findings, the scientists hope to develop approaches for novel treatments and medications.
More information: Andrés Uribe-Mariño et al. Prefrontal cortex corticotropin-releasing hormone receptor 1 conveys acute stress-induced executive dysfunction, Biological Psychiatry (2016). DOI: 10.1016/j.biopsych.2016.03.2106

Journal reference: Biological Psychiatry search and more info

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