Pretty much useless with all these big words and no translation of what foods and amounts you need to have to fall into the correct quintile. Does no one vet these papers for readability?
Abstract
BACKGROUND:
Although
increased fruit intake reduces cardiovascular disease (CVD) risk, which
fruits are most beneficial and what key constituents are responsible
are unclear. Habitual intakes of flavonoids, specifically anthocyanins
and flavanones, in which >90% of habitual intake is derived from
fruit, are associated with decreased CVD risk in women, but associations
in men are largely unknown.
OBJECTIVE:
We
examined the relation between habitual anthocyanin and flavanone intake
and coronary artery disease and stroke in the Health Professionals
Follow-Up Study.
DESIGN:
We
followed 43,880 healthy men who had no prior diagnosed CVD or cancer.
Flavonoid intake was calculated with the use of validated food-frequency
questionnaires.
RESULTS:
During
24 y of follow-up, 4046 myocardial infarction (MI) and 1572 stroke
cases were confirmed by medical records. Although higher anthocyanin
intake was not associated with total or fatal MI risk, after
multivariate adjustment an inverse association with nonfatal MI was
observed (HR: 0.87; 95% CI: 0.75, 1.00; P = 0.04; P-trend = 0.098); this
association was stronger in normotensive participants (HR: 0.81; 95%
CI: 0.69, 0.96; P-interaction = 0.03). Anthocyanin intake was not
associated with stroke risk. Although flavanone intake was not
associated with MI or total stroke risk, higher intake was associated
with a lower risk of ischemic stroke (HR: 0.78; 95% CI: 0.62, 0.97; P =
0.03, P-trend = 0.059), with the greatest magnitude in participants aged
≥65 y (P-interaction = 0.04).
CONCLUSIONS:
Higher
intakes of fruit-based flavonoids were associated with a lower risk of
nonfatal MI and ischemic stroke in men. Mechanistic studies and clinical
trials are needed to unravel the differential benefits of anthocyanin-
and flavanone-rich foods on cardiovascular health.
KEYWORDS:
anthocyanins; flavanones; flavonoids; heart disease; men; stroke
- [PubMed - as supplied by publisher]
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