http://link.springer.com/article/10.1007/s12035-016-0236-1
Article
- First Online:
- 04 November 2016
DOI:
10.1007/s12035-016-0236-1
- Cite this article as:
- Wang, J., Gao, L., Yang, YL. et al. Mol Neurobiol (2016). doi:10.1007/s12035-016-0236-1
- 2 Downloads
Abstract
Circulating
brain-derived neurotrophic factor (BDNF) has been highlighted as being a
key regulator of rehabilitation-induced recovery after stroke. The aim
of this study was to evaluate the association between serum levels of
BDNF and functional outcome and mortality events in a 3-month follow-up
study in a cohort of patients with an acute ischemic stroke (AIS). From
January 2015 to December 2015, consecutive first-ever AIS patients
admitted to the Department of Emergency of our hospital were identified.
Serum BDNF levels were measured at admission. Functional outcome was
evaluated at 3 months using the modified Rankin scale (m-Rankin). We
used logistic regression models to assess the relationship between BDNF
levels and functional outcome or mortality. In this study, 204 patients
were included. Patients with poor outcomes and non-survivors had
significantly lower BDNF levels on admission (P < 0.0001
all). Multivariate logistic regression analysis adjusted for common
risk factors showed that BDNF levels in the lowest interquartile (≤1st
9.2 ng/ml) was an independent predictor of functional outcome (odds
ratios [OR] = 3.75; 95 % confidence interval [CI], 2.43–8.12) and
mortality (OR = 4.04; 95 % CI, 2.07–9.14). The area under the receiver
operating characteristic curve of BDNF was 0.77 (95 % CI, 0.70–0.84) for
functional outcome and 0.79 (95 % CI, 0.71–0.86) for mortality. The
findings indicated that low serum levels of BDNF at admission were
significantly associated with poor short-term functional outcome and
mortality, suggesting that BDNF may serve as a biomarker of poor
function outcome after stroke.
No comments:
Post a Comment