Deans' stroke musings: Young blood does not reverse aging in old mice, UC Berkeley study finds

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, November 28, 2016

Young blood does not reverse aging in old mice, UC Berkeley study finds

I disagree with the conclusion.
http://scienmag.com/young-blood-does-not-reverse-aging-in-old-mice-uc-berkeley-study-finds/
A new study from UC Berkeley found that tissue health and repair dramatically decline in young mice when half of their blood is replaced with blood from old mice. The study argues against the rejuvenating properties of young blood and points to old blood, or molecules within, as driving the aging process.
"Our study suggests that young blood by itself will not work as effective medicine," said Irina Conboy, associate professor in the Department of Bioengineering at UC Berkeley. "It's more accurate to say that there are inhibitors in old blood that we need to target to reverse aging." (And young blood would be the easiest solution, don't try for the perfect when good is good enough.)

The study will be published Nov. 22 in the journal Nature Communications. The research was supported by funding from the National Institutes of Health, SENS Research Foundation, Rogers' Family and Calico.
In 2005, Conboy and colleagues published a study in Nature that found evidence for tissue rejuvenation in older mice when they are surgically joined to younger mice so that blood is exchanged between the two. Despite remaining questions about the mechanism underlying this rejuvenation, media coverage of the study fixated on the potential of young blood to reverse the aging process, and on comparisons to vampires, which was not the takeaway from the study, Conboy said. In the years since the 2005 study, scientists have spent millions to investigate the potential medical properties of youthful blood with enterprises emerging to infuse old people with young blood.
"What we showed in 2005 was evidence that aging is reversible and is not set in stone," Conboy said. "Under no circumstances were we saying that infusions of young blood into elderly is medicine."
Blood exchange in humans is FDA-approved for a few devastating illnesses (auto-immunity, for example, where self-reacting antibodies are removed), but high volume or repeated additions of blood or its components to genetically different people is known to have side effects of immune rejection, leading to organ failure.
While the experimental model used in the 2005 study found evidence that some aspects of aging may be reversed, the techniques used in the study do not allow scientists to precisely control the exchange of blood, which is necessary to dig deeper into blood's effect on aging.