Deans' stroke musings: Early intervention in brain inflammatory pathways may improve stroke recovery

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, November 29, 2016

Early intervention in brain inflammatory pathways may improve stroke recovery

Followup needed in humans, bet it doesn't occur for decades.

Early intervention in brain inflammatory pathways may improve stroke recovery

Intracerebral hemorrhage is a type of stroke characterized by the rupture of a blood vessel within the brain. When the brain is exposed to blood, local immune cells become activated, triggering inflammation that promotes ongoing injury in the days and weeks after the initial stroke event.

This month in the JCI, work from Laura Sansing's lab at Yale School of Medicine examined the pathways in the brain that drive injury-producing inflammation. They identified a signaling protein that plays a pivotal role in activating immune system-mediated damage after intracerebral hemorrhage. In a mouse model, they observed that intracerebral hemorrhage-driven inflammation began to clear up at the same time as the TGF-β1 pathway was activated in local immune cells.

Treating mice with TGF-β1 immediately after the initial injury reduced pro-inflammatory signals and improved motor function compared to untreated mice. In a patient population, they also observed that higher bloodstream levels of TGF-β1 in the first 3 days following intracerebral hemorrhage predicted better outcomes 3 months into recovery.

Together, these results suggest that targeting the TGF-β1 pathway may have protective effects in individuals recovering from stroke and brain injury.

More information: Roslyn A. Taylor et al, TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage, Journal of Clinical Investigation (2016). DOI: 10.1172/JCI88647

Provided by: JCI Journals