Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, November 26, 2016

Effects of ezetimibe and anticoagulant combined therapy on progressing stroke: a randomized, placebo-controlled study

So which of these 5 causes of neuronal cascade of death is this addressing? Or was this a lucky shot in the dark guess? Which happens when we have NO strategy. We can expect no useful followup until we get stroke survivors in charge with a single-minded focus.
http://link.springer.com/article/10.1007%2Fs00415-016-8283-0

  • Lan Yang
  • Pingping Zhao
  • Jing Zhao
  • Juan Wang
  • Lei Shi
  • Xiaopeng Wang
  • Lan Yang
    • 1
  • Pingping Zhao
    • 2
  • Jing Zhao
    • 1
  • Juan Wang
    • 1
  • Lei Shi
    • 3
  • Xiaopeng Wang
    • 1
  1. 1.The Second Hospital of Hebei Medical UniversityShijiazhuangChina
  2. 2.The Third Hospital of ShijiazhuangShijiazhuangChina
  3. 3.Quyang County People’s HospitalQuyangChina
Original Communication
DOI: 10.1007/s00415-016-8283-0
Cite this article as:
Yang, L., Zhao, P., Zhao, J. et al. J Neurol (2016) 263: 2438. doi:10.1007/s00415-016-8283-0

Abstract

Despite the high prevalence of progressing stroke in patients with acute stroke, preventative treatments are still the unmet needs for those patients. The aim of this study was to evaluate, prospectively, the efficacy and safety of ezetimibe in the prevention of acute progressing stroke and thereby the improvement of patient outcome. A total of 423 patients (267 men and 156 women with a mean age of 65.2 years) were randomly assigned to receive ezetimibe (10 mg daily oral administration, n = 209) or placebo (n = 214) for 14 consecutive days. Analytical procedures performed at baseline (i.e., day 1) and 14 days after the treatments were completed. These included a real-time three-dimensional ultrasound (RT-3DU) examination for carotid plaque volume, clinical laboratory analyses of serum levels of IL-6 and MMP-9, as well as lipid parameters and liver dysfunction marker ALT and TBIL. Ezetimibe significantly reduced the average NIHSS score after 14 days of treatment and attenuated the stroke progression rate, which was associated with reduction in carotid plaque volume and attenuation of serum levels of IL-6, MMP-9, and LDL, without inducing liver dysfunction. Ezetimibe treatment may be a beneficial and effective strategy for preventing progressing stroke.

Keywords

EzetimibeProgressing strokeReal-time three-dimensional ultrasoundCarotid plaqueInterleukin-6Matrix metallopeptidase 9

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