I started writing 4 blog posts about sonic hedgehog back in 2012. Yet we still have absolutely nothing done with it.
http://www.sciencedirect.com/science/article/pii/S0166223616301382
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Sonic
hedgehog (Shh) is a secreted protein that controls the patterning of
neural progenitor cells, and their neuronal and glial progeny, during
development. Emerging findings suggest that Shh also has important roles
in the formation and plasticity of neuronal circuits in the
hippocampus, a brain region of fundamental importance in learning and
memory. Shh mediates activity-dependent and injury-induced hippocampal
neurogenesis. Activation of Shh receptors in the dendrites of
hippocampal neurons engages a trans-neuronal signaling pathway that
accelerates axon outgrowth and enhances glutamate release from
presynaptic terminals. Impaired Shh signaling may contribute to the
pathogenesis of several developmental and adult-onset neurological
disorders that affect the hippocampus, suggesting a potential for
therapeutic interventions that target Shh pathways.
Trends
Shh regulates hippocampal stem cell proliferation and neuronal differentiation.
Cell
responses to Shh are mediated by a membrane receptor (Patched), a
transducer protein (Smoothened), and Gli transcription factors.
Regulation of axon elongation is a function of Shh in the developing and adult hippocampus.
Emerging findings suggest roles for Shh signaling in hippocampal synaptic plasticity.
Results
of studies of animal models suggest potential therapeutic applications
of Shh receptor agonists in several neurological disorders.
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