https://www.mdlinx.com/neurology/medical-news-article/2016/11/07/aging-process-coenzyme-nad/6907659?
University of Copenhagen Faculty of Health and Medical Sciences News, 11/07/2016
The
coenzyme NAD+ plays a main role in aging processes. In mice and
roundworm adding the substance can both extend life and postpone the
onset of aging processes. New research conducted at the Center for
Healthy Aging and the American National Institute of Health shows that
this new knowledge will eventually be able to help patients with
Alzheimer’s and Parkinson’s disease.
Previous research has shown that a main process in aging is the capacity of the cells to keep our genes, our DNA, more or less intact. However, changes in the cells’ power stations, the mitochondria, also affect aging processes. An international team of researchers from the Center for Healthy Aging at the University of Copenhagen and the National Institute of Health in the United States has shown that the substance NAD+ bridges the gap between two main aging theories – repairs to the DNA and poor functioning mitochondria.
The results were published in the journal Cell Metabolism.
"Our new study shows an age–dependent decrease in the level of NAD+, and this decrease is far greater for organisms with early aging and a lack of DNA repairs. We were surprised to see that adding NAD+ postponed both the aging processes of the cells and extended life in worms and in a mouse model", says Professor Vilhelm Bohr from the Center for Healthy Aging and the National Institute of Health.
Previous research has shown that a main process in aging is the capacity of the cells to keep our genes, our DNA, more or less intact. However, changes in the cells’ power stations, the mitochondria, also affect aging processes. An international team of researchers from the Center for Healthy Aging at the University of Copenhagen and the National Institute of Health in the United States has shown that the substance NAD+ bridges the gap between two main aging theories – repairs to the DNA and poor functioning mitochondria.
The results were published in the journal Cell Metabolism.
"Our new study shows an age–dependent decrease in the level of NAD+, and this decrease is far greater for organisms with early aging and a lack of DNA repairs. We were surprised to see that adding NAD+ postponed both the aging processes of the cells and extended life in worms and in a mouse model", says Professor Vilhelm Bohr from the Center for Healthy Aging and the National Institute of Health.
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