Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Sunday, November 27, 2016

The role of the miR-17–92 cluster in neurogenesis and angiogenesis in the central nervous system of adults

We need followup research which is so easy to accomplish. You put an RFP out to researchers, pay for it with foundation grants and write the results up in a stroke protocol available in a public database.
http://onlinelibrary.wiley.com/doi/10.1002/jnr.23991/full



  • SIGNIFICANCE In this review, the role of miR-17–92 cluster in neuronal and vascular plasticity, and its potential as a novel therapeutic target for CNS injury are discussed.
  • This work was supported by grants from the National Natural Science Foundation of China (NSFC, 81171719) and from Chongqing Natural Science of Foundation of China (CSTC, 2008 BB5281).

Abstract

It is well known that neurogenesis is not the only concern for the fully functional recovery after brain or spinal cord injury, as it has been shed light on the critical role of angiogenesis in improving neurological functional recovery. Angiogenesis and neurogenesis coordinately interact with each other in the developing and adult brain, during which they may respond to similar mediators and receptors, in which they share a common posttranscriptional regulator: the miR-17–92 cluster. The miR-17–92 cluster was initially described as an oncogene and was later demonstrated to drive key physiological and pathological responses during development and diseases respectively. It has been reported that the miR-17–92 cluster regulates both neurogenesis and angiogenesis. The miR-17–92 cluster modulates neural progenitor cells proliferation not only during development but also during neurological disorders such as stroke. It has also been shown that the endothelial miR-17–92 cluster regulates angiogenesis during embryonic stage and adulthood. In this review, we have discussed the actions of the miR-17–92 cluster in neuronal and vascular plasticity, and its potential as a novel therapeutic strategy for CNS injury. © 2016 Wiley Periodicals, Inc.

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