1. A documented 33% dementia chance post-stroke from an Australian study? May 2012.
2. Then this study came out and seems to have a range from 17-66%. December 2013.
3. A 20% chance in this research. July 2013.
Non-Invasive Eye Scan Could Detect Signs of Alzheimer’s Years Before Patients Show Symptoms
August 18, 2017
LOS
ANGELES -- August 18, 2017 -- Alzheimer’s disease affects the retina
similarly to the way it affects the brain, according to a study
published in JCI Insight.
The study also revealed that an investigational, non-invasive eye scan could detect the key signs of Alzheimer’s disease years before patients experience symptoms.
Using a high-definition eye scan developed especially for the study, researchers detected the crucial warning signs of Alzheimer’s disease: amyloid-beta deposits. The findings represent a major advancement toward identifying people at high risk for the debilitating condition years sooner.
“The findings suggest that the retina may serve as a reliable source for Alzheimer’s disease diagnosis,” said Maya Koronyo-Hamaoui, PhD, Cedars-Sinai Medical Center, Los Angeles, California. “One of the major advantages of analysing the retina is the repeatability, which allows us to monitor patients and potentially the progression of their disease.”
Another key finding from the study was the discovery of amyloid plaques in previously overlooked peripheral regions of the retina. The researchers found that the amount of plaque in the retina correlated with plaque amount in specific areas of the brain.
“Now we know exactly where to look to find the signs of Alzheimer’s disease as early as possible,” said Yosef Koronyo, Cedars-Sinai Medical Center.
“Our hope is that eventually the investigational eye scan will be used as a screening device to detect the disease early enough to intervene and change the course of the disorder with medications and lifestyle changes,” said Keith L. Black, MD, Cedars-Sinai Medical Center.
The study included 16 patients with Alzheimer’s disease. The patients drank a solution that included curcumin, which causes amyloid plaque in the retina to light up and be detected by a modified scanning laser ophthalmoscope. The patients were then compared to a group of 37 younger, cognitively normal individuals.
Histological examination uncovered classical and neuritic-like Abeta deposits with increased retinal amyloid-beta 42 plaques (4.7-fold; P = .0063) and neuronal loss (P = .0023) in patients with AD versus matched controls. Retinal amyloid-beta plaque mirrored brain pathology, especially in the primary visual cortex.
Reference: https://doi.org/10.1172/jci.insight.93621
SOURCE: Cedars-Sinai Medical Center
The study also revealed that an investigational, non-invasive eye scan could detect the key signs of Alzheimer’s disease years before patients experience symptoms.
Using a high-definition eye scan developed especially for the study, researchers detected the crucial warning signs of Alzheimer’s disease: amyloid-beta deposits. The findings represent a major advancement toward identifying people at high risk for the debilitating condition years sooner.
“The findings suggest that the retina may serve as a reliable source for Alzheimer’s disease diagnosis,” said Maya Koronyo-Hamaoui, PhD, Cedars-Sinai Medical Center, Los Angeles, California. “One of the major advantages of analysing the retina is the repeatability, which allows us to monitor patients and potentially the progression of their disease.”
Another key finding from the study was the discovery of amyloid plaques in previously overlooked peripheral regions of the retina. The researchers found that the amount of plaque in the retina correlated with plaque amount in specific areas of the brain.
“Now we know exactly where to look to find the signs of Alzheimer’s disease as early as possible,” said Yosef Koronyo, Cedars-Sinai Medical Center.
“Our hope is that eventually the investigational eye scan will be used as a screening device to detect the disease early enough to intervene and change the course of the disorder with medications and lifestyle changes,” said Keith L. Black, MD, Cedars-Sinai Medical Center.
The study included 16 patients with Alzheimer’s disease. The patients drank a solution that included curcumin, which causes amyloid plaque in the retina to light up and be detected by a modified scanning laser ophthalmoscope. The patients were then compared to a group of 37 younger, cognitively normal individuals.
Histological examination uncovered classical and neuritic-like Abeta deposits with increased retinal amyloid-beta 42 plaques (4.7-fold; P = .0063) and neuronal loss (P = .0023) in patients with AD versus matched controls. Retinal amyloid-beta plaque mirrored brain pathology, especially in the primary visual cortex.
Reference: https://doi.org/10.1172/jci.insight.93621
SOURCE: Cedars-Sinai Medical Center
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