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Does Caffeine Consumption Increase the Risk of New-Onset Atrial Fibrillation?
Abdelfattah R.a · Kamran H.b · Lazar J.b · Kassotis J.c Author affiliations | |
Cardiology 2018;140:106–114
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Article / Publication Details
Received: September 06, 2017
Accepted: May 04, 2018
Published online: July 02, 2018
Issue release date: Published online first
Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 3
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
Accepted: May 04, 2018
Published online: July 02, 2018
Issue release date: Published online first
Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 3
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
Abstract
Objective: Caffeine has been considered a trigger for atrial fibrillation (AF). We conducted a meta-analysis including a dose-response analysis to assess the relationship between caffeine consumed and incidence of AF.Methods: Data from selected studies represented 176,675 subjects (AF in 9,987 [5.7%]). Caffeine content varied widely, ranging from 40 to 180 mg per cup of coffee. For purposes of the calculations in this study, we assumed 140 mg of caffeine in a standard 12-oz cup of coffee.
Results: No significant difference was found in AF incidence when the subjects consuming less than 2 cups of coffee per day were compared to subjects with higher consumption, 1.068 (0.937–1.216). The risk of AF was higher among subjects consuming less than 2 cups of coffee daily when compared to higher daily consumption subjects. A lower incidence of AF was found among people consuming more than 436 mg daily.
Conclusion: The incidence of AF is not increased by coffee consumption. In fact, we found a lower incidence of AF when caffeine consumption exceeded 436 mg/day. Therefore, based on available evidence there is no association between caffeine intake and AF risk.
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