Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, July 18, 2018

Eliminating senescent cells extends healthy life in mice

I assume you want a healthy life into old age. So ask your doctor to follow this up with human research.
https://www.nih.gov/news-events/nih-research-matters/eliminating-senescent-cells-extends-healthy-life-mice
As the body ages, physical abilities decline. This can lead to difficulty with daily tasks and eventually loss of the ability to live independently. Senescent cells are thought to play a role in this aspect of the aging process. Cells that are senescent no longer do their jobs or divide, but are still alive. In addition, they release molecules that can harm healthy cells around them and may even induce other cells to become senescent.
A team of researchers led by Dr. James Kirkland of the Mayo Clinic wanted to understand how senescent cells contribute to the physical effects of aging. Their study was supported by NIH’s National Institute on Aging (NIA) and others. The findings were published on July 9, 2018, in Nature Medicine.
The scientists first transplanted a small number of senescent fat cells into healthy young and middle-aged mice, and measured how those cells impacted strength, endurance, and other measures of physical health. For comparison, control mice were given fat cells that weren’t senescent. 
One month after transplantation, mice who received the senescent cells had impaired walking speed, physical endurance, and grip strength compared to control mice. Larger doses of senescent cells caused greater impairment over time. Notably, middle-aged mice transplanted with senescent cells had a 5-fold higher risk of death than control mice over the following year.
The negative physical effects observed didn’t appear to be due to rejection of the transplanted cells by the body. The effects of the senescent cells also lasted longer in the body than the cells themselves. Results suggested that the senescent cells may have caused previously healthy cells to become senescent.
The team next tested whether drugs that are known to eliminate senescent cells, called senolytics, could slow or reverse these effects. A cocktail of two senolytic drugs, dasatinib and quercetin, was given to young mice either at the same time as transplantation of senescent cells or 5 weeks afterward. In both cases, the drug combination improved physical functioning. The effects of a single treatment lasted several months.
When the researchers gave the cocktail over 4 months to mice who had aged naturally to the human equivalent of 75 to 90 years of age, they saw similar improvements in physical abilities compared with untreated mice. Mice who received the drugs also lived 36% longer on average and were no more frail near their delayed time of death than controls.
“We can say with certainty that senescent cells can cause health problems in young mice, including causing physical dysfunction and lowering survival rates, and that the use of senolytics can significantly improve both health span and life span in much older naturally aged animals,” Kirkland says.
The authors caution that clinical trials are needed to test the safety and effectiveness of this approach in people.

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