A question SPECIFICALLY for your doctor to answer. Doesn't know, then the competent thing to do is get research going to find the answer. DOING NOTHING IS NOT OK.
Can Aspirin Decrease the Rate of Intracranial Aneurysm Growth?
In
patients with multiple intracranial aneurysms, aspirin may
significantly decrease the rate of aneurysm growth over time, according
to a study published in the Journal of Neurosurgery.
While aneurysms >7 mm are more likely to rupture, some small aneurysms grow, increasing the risk that they may rupture. Therefore, physicians observe small, unruptured aneurysms over time by asking patients to undergo regularly scheduled imaging examinations.
While there has been some evidence that aspirin may reduce the risk of aneurysm rupture due to the drug’s anti-inflammatory effect on the weakened aneurysm wall, “to date, there is no medical treatment to arrest aneurysm growth and subsequent progression to rupture,” the authors wrote.
For the current study, Mario Zanaty, MD, University of Iowa Hospitals and Clinics, Iowa City, Iowa, and colleagues identified 146 patients harbouring multiple intracranial aneurysms, ≤5 mm in diameter, which had been observed for at least 5 years. The researchers also gathered information on the patients’ demographics, earlier medical history, the rupture status of designated primary aneurysms, aneurysms’ angiographic features, and treatment modalities.
In the cohort of patients, the researchers identified a total of 375 intracranial aneurysms. At the initial encounter, 146 aneurysms were treated and the remaining 229 aneurysms (2 to 5 mm) were observed.
During the follow-up period, 10.48% of the aneurysms grew. All aneurysms observed to grow later underwent treatment. None of the observed aneurysms ruptured.
Multivariate analysis showed that aspirin was significantly associated with a decreased rate of growth (odds ratio [OR] = 0.19; 95% confidence interval [CI], 0.05-0.63).
Variables associated with an increased rate of growth included hypertension (OR =14.38; 95% CI, 3.83-53.94), drug abuse (OR = 11.26; 95% CI, 1.21-104.65), history of polycystic kidney disease (OR = 9.48; 95% CI, 1.51-59.35), and subarachnoid haemorrhage at presentation (OR = 5.91; 95% CI, 1.83-19.09).
On the basis of the statistical analyses, use of aspirin appears to exert a protective effect against aneurysm growth and very likely against future rupture.
The authors point out that their findings are observational and that future interventional studies should be conducted.
“This study is very promising, as it outlines for the first time the potential therapeutic effect of aspirin in decreasing aneurysm growth,” concluded David Hasan, MD, University of Iowa Hospitals and Clinics. “If proven in a larger study, this could offer the first cheap, effective, over-the-counter therapeutic agent that could halt aneurysm growth and prevent rupture.”
Reference: https://thejns.org/view/journals/j-neurosurg/aop/article-10.3171-2019.6.JNS191273/article-10.3171-2019.6.JNS191273.xml
SOURCE: Journal of Neurosurgery Publishing Group
While aneurysms >7 mm are more likely to rupture, some small aneurysms grow, increasing the risk that they may rupture. Therefore, physicians observe small, unruptured aneurysms over time by asking patients to undergo regularly scheduled imaging examinations.
While there has been some evidence that aspirin may reduce the risk of aneurysm rupture due to the drug’s anti-inflammatory effect on the weakened aneurysm wall, “to date, there is no medical treatment to arrest aneurysm growth and subsequent progression to rupture,” the authors wrote.
For the current study, Mario Zanaty, MD, University of Iowa Hospitals and Clinics, Iowa City, Iowa, and colleagues identified 146 patients harbouring multiple intracranial aneurysms, ≤5 mm in diameter, which had been observed for at least 5 years. The researchers also gathered information on the patients’ demographics, earlier medical history, the rupture status of designated primary aneurysms, aneurysms’ angiographic features, and treatment modalities.
In the cohort of patients, the researchers identified a total of 375 intracranial aneurysms. At the initial encounter, 146 aneurysms were treated and the remaining 229 aneurysms (2 to 5 mm) were observed.
During the follow-up period, 10.48% of the aneurysms grew. All aneurysms observed to grow later underwent treatment. None of the observed aneurysms ruptured.
Multivariate analysis showed that aspirin was significantly associated with a decreased rate of growth (odds ratio [OR] = 0.19; 95% confidence interval [CI], 0.05-0.63).
Variables associated with an increased rate of growth included hypertension (OR =14.38; 95% CI, 3.83-53.94), drug abuse (OR = 11.26; 95% CI, 1.21-104.65), history of polycystic kidney disease (OR = 9.48; 95% CI, 1.51-59.35), and subarachnoid haemorrhage at presentation (OR = 5.91; 95% CI, 1.83-19.09).
On the basis of the statistical analyses, use of aspirin appears to exert a protective effect against aneurysm growth and very likely against future rupture.
The authors point out that their findings are observational and that future interventional studies should be conducted.
“This study is very promising, as it outlines for the first time the potential therapeutic effect of aspirin in decreasing aneurysm growth,” concluded David Hasan, MD, University of Iowa Hospitals and Clinics. “If proven in a larger study, this could offer the first cheap, effective, over-the-counter therapeutic agent that could halt aneurysm growth and prevent rupture.”
Reference: https://thejns.org/view/journals/j-neurosurg/aop/article-10.3171-2019.6.JNS191273/article-10.3171-2019.6.JNS191273.xml
SOURCE: Journal of Neurosurgery Publishing Group
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