Deans' stroke musings: Beyond the Brain: The Systemic Pathophysiological Response to Acute Ischemic Stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, June 5, 2020

Beyond the Brain: The Systemic Pathophysiological Response to Acute Ischemic Stroke

Now if we just had some stroke leadership that would take this and create a strategy with it to solve stroke. BUT NO, WE HAVE NOTHING IN STROKE, NO LEADERSHIP, NO STRATEGY,ABSOLUTELY NOTHING!

Beyond the Brain: The Systemic Pathophysiological Response to Acute Ischemic Stroke

Maria H.H. Balch^{¹^,²}^, Shahid M. Nimjee^¹^, Cameron Rink^¹^, Yousef Hannawi^³

^¹Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA
^²Department of Biomedical Education and Anatomy, The Ohio State University College of Medicine, Columbus, OH, USA
^³Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Correspondence Yousef Hannawi ,Tel: +1-614-685-7234, Fax: +1-614-366-7004 , Email: yousefhannawi@yahoo.com

Received: November 2, 2019 Revised: January 28, 2020 Accepted: March 17, 2020 Published online: May 31, 2020

Abstract

Stroke research has traditionally focused on the cerebral processes following ischemic brain injury, where oxygen and glucose deprivation incite prolonged activation of excitatory neurotransmitter receptors, intracellular calcium accumulation, inflammation, reactive oxygen species proliferation, and ultimately neuronal death. A recent growing body of evidence, however, points to far-reaching pathophysiological consequences of acute ischemic stroke. Shortly after stroke onset, peripheral immunodepression in conjunction with hyperstimulation of autonomic and neuroendocrine pathways and motor pathway impairment result in dysfunction of the respiratory, urinary, cardiovascular, gastrointestinal, musculoskeletal, and endocrine systems. These end organ abnormalities play a major role in the morbidity and mortality of acute ischemic stroke. Using a pathophysiology-based approach, this current review discusses the pathophysiological mechanisms following ischemic brain insult that result in end organ dysfunction. By characterizing stroke as a systemic disease, future research must consider bidirectional interactions between the brain and peripheral organs to inform treatment paradigms and develop effective, comprehensive therapeutics for acute ischemic stroke.