Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, August 30, 2021

Evolution of FMRI activation in the perilesional primary motor cortex and cerebellum with rehabilitation training-related motor gains after stroke: a pilot study

 But with no specific protocols listed and no objective damage starting point this is still almost completely useless

Evolution of FMRI activation in the perilesional primary motor cortex and cerebellum with rehabilitation training-related motor gains after stroke: a pilot study

 Yun Dong,MD,PhD,Carolee J.Winstein,PhD,Richard Albistegui-DuBois,PhD,and Bruce H.Dobkin,MD
Background
Previous studies report that motor recovery after partial destruction of the primary motor cortex (M1) may be(weasel words are useless to survivors.) associated with adaptive functional reorganization within spared M1.
Objective
To test feasible methodologies for evaluating relationships between behavioral gains facilitated by rehabilitative training and functional adaptations in perilesional M1 and the cerebellum.
Methods
Four patients with hemiparesis for more than 3 months after a cortical lesion partially within M1 and 12 healthy volunteers participated.Functional magnetic resonance imaging (fMRI) using a finger-tapping task and concurrent behavioral assessments, including the Fugl-Meyer Motor Assessment of the upper extremity and the Wolf Motor Function Test,were conducted before and after 2 weeks of arm focused training;2 patients were further examined 6 and 12 months later to evaluate long-term persistence of brain behavior adaptations.
Results
All patients showed higher activation magnitude in perilesional M1 than healthy controls before and after therapy.Further long-term functional gains paralleled the decrease of activation magnitude in perilesional M1 in the 2 more impaired cases.
Conclusion  
The evolution of suggestive correlations between serial scans of fMRI adaptive activity within the primary motor cortex and the cerebellum in relation to relevant behavioral changes over the course of 2 weeks of task specific therapy and then no formal therapy suggests that repeated assessments may be best for monitoring therapy induced neuroplasticity.This approach may help develop optimal rehabilitation strategies to maximize post stroke motor recovery as well as improve the search for brain behavior correlations in functional neuroimaging research.
Key Words:
Stroke rehabilitation—fMRI—Wol fMotor Function Test—Primary motor cortex—Constraint-induced movement therapy—Adaptive reorganization.
Post stroke recovery of motor function with and without specific rehabilitation training has been attributed in part to adaptive functional reorganization within the central nervous system.1,2The under-lying neurophysiological mechanisms may include changes in neuronal membrane excitability,synaptic strengthening, synaptogenesis, dendritic arborization,fiber sprouting from surviving neurons,and recruitment of nearby and remote neuronal ensembles after focal brain injury.3,4Functional reorganization within the intact area surrounding an infarct restricted to the primary motor cortex (M1) was observed over the temporal course of recovery from stroke using functional magnetic resonance imaging (fMRI). The studies supported the notion that human M1 is capable of functional adaptation comparable to that seen in primate experiments.5,6Growing evidence from both animal and human studies suggests the importance of perilesional adaptive reorganization and the potential modulative effects of focused,intensive rehabilitative training in facilitating this use-dependent reorganization.7,8With the use of advanced neuroimaging technologies,rehabilitation therapy-induced adaptive reorganization within putative motor networks has been investigated in chronic stroke patients who received constraint induced movement therapy (CIMT).9-12The correlates between motor functional gains and changes in physiological signals have differed across studies,however.To best elucidate the mechanisms mediating cerebral adaptations after stroke,studies must account for inter subject variability in initial impairment level(Yeah, like an objective damage diagnosis?),lesion location and size,trajectory of behavioral gains associated with time and motor learning experience,and dose of rehabilitation therapy.13 between intensive training-related motor functional improvement and adaptive reorganization in perilesionalM1 in patients with partial M1 damage.We performed consecutive fMRI scans with concurrent behavioral assessments in 4 patients who had a single stroke involving a portion ofM1 before,immediately after 2 weeks of CIMT,and,in 2 willing subjects,6 and 12 months later.The aims of the study were 2-fold:1) to test the hypothesis that rehabilitative training-related behavioral gains are associated with specific functional adaptations within the intact perilesional M1 and the remotely connected cerebellum and 2) to test methods for evaluating direct brain-behavior correlates and generate preliminary data for larger scale studies.

No comments:

Post a Comment