Deans' stroke musings: Time window for ischemic stroke first mobilization effectiveness: Protocol for an investigator-initiated prospective multicenter randomized 3-arm clinical trial

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, August 26, 2021

Time window for ischemic stroke first mobilization effectiveness: Protocol for an investigator-initiated prospective multicenter randomized 3-arm clinical trial

You mean you're repeating what is already known?

Early Mobilization (10 posts to May 2014)

Time window for ischemic stroke first mobilization effectiveness: Protocol for an investigator-initiated prospective multicenter randomized 3-arm clinical trial

Physical Therapy , Volume 101(5)

NARIC Accession Number: J86625. What's this?
ISSN: 0031-9023.
Author(s): Zheng, Yu ; Yan, Chengjie ; Shi, Haibin ; Niu, Qi ; Liu, Qianghui ; Lu, Shanshan ; Zhang, Xintong; Cheng, Yihui ; Teng, Meiling ; Wang, Lu ; Zhang, Xiu ; Hu, Xiaorong ; Li, Jian ; Lu, Xiao ; Reinhardt, Jan D..
Publication Year: 2021.
Number of Pages: 11.

Abstract:

Article presents the protocol for a study investigating the optimal time window for initiating mobilizing after acute ischemic stroke. The TIME Trial is a pragmatic, investigator-initiated, multi-center, randomized, 3-arm parallel group, clinical trial. This trial will be conducted in 57 general hospitals in mainland China and will enroll 6,033 eligible patients with acute ischemic stroke. Participants will be randomly allocated to either (1) the very early mobilization group in which mobilization is initiated within 24 hours from stroke onset, (2) the early mobilization group in which mobilization begins between 24 and 72 hours poststroke, or (3) the late mobilization group in which mobilization is started after 72 hours poststroke. The mobilization protocol is otherwise standardized and identical for each comparison group. Mobilization is titrated by baseline mobility level and progress of patients throughout the intervention period. The primary outcome is death or disability assessed with the modified Rankin scale at 3 months poststroke. Secondary outcomes include impairment score of the National Institutes of Health Stroke Scale, dependence in activities of daily living as measured using the modified Barthel Index, cognitive ability assessed with the Mini-Mental State Examination, incidence of adverse events, hospital length of stay, and total medical costs. The effect of timing is isolated from the effect of type and dose of mobilization by otherwise applying a standard mobilization protocol across groups. The TIME Trial may, therefore, contribute to increasing the knowledge base regarding the optimal time window for initiating mobilization after acute ischemic stroke.
Descriptor Terms: BODY MOVEMENT, EARLY INTERVENTION, INTERNATIONAL REHABILITATION, PHYSICAL THERAPY, REHABILITATION RESEARCH, RESEARCH METHODOLOGY, STROKE.

Can this document be ordered through NARIC's document delivery service*?: Y.

Citation: Zheng, Yu , Yan, Chengjie , Shi, Haibin , Niu, Qi , Liu, Qianghui , Lu, Shanshan , Zhang, Xintong, Cheng, Yihui , Teng, Meiling , Wang, Lu , Zhang, Xiu , Hu, Xiaorong , Li, Jian , Lu, Xiao , Reinhardt, Jan D.. (2021). Time window for ischemic stroke first mobilization effectiveness: Protocol for an investigator-initiated prospective multicenter randomized 3-arm clinical trial. Physical Therapy , 101(5) Retrieved 8/26/2021, from REHABDATA database.