Deans' stroke musings: Caffeinol at the Receptor Level Anti-Ischemic Effect of N-Methyl-d-Aspartate Receptor Blockade Is Potentiated by Caffeine

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, May 13, 2022

Caffeinol at the Receptor Level Anti-Ischemic Effect of N-Methyl-d-Aspartate Receptor Blockade Is Potentiated by Caffeine

Well shit, this was originally written 12 years ago but because we have NO LEADERSHIP OR STRATEGY, nothing seems to have occurred. You obviously can't bring in coffee and tiny bottles of alcohol to your survivors immediately in the hospital.

Caffeinol at the Receptor Level: Anti-Ischemic Effect of N-Methyl-d-Aspartate Receptor Blockade Is Potentiated by Caffeine

and

Originally published31 Dec 2009https://doi.org/10.1161/STROKEAHA.109.562900Stroke. 2010;41:363–367

Other version(s) of this article

Abstract

Background and Purpose—Although caffeinol (a combination of a low dose of caffeine and ethanol) was shown to robustly reduce stroke damage in experimental models and is now in clinical evaluation for treatment of ischemic stroke, little is known about the potential mechanism of its action.

Methods—We used an in vivo excitotoxicity model based on intracortical infusion of N-methyl-d-aspartate (NMDA) and a model of reversible focal ischemia to demonstrate NMDA receptor inhibition as a potential mechanism of caffeinol anti-ischemic activity.

Results—Caffeinol reduced the size of excitotoxic lesion, and substitution of ethanol in caffeinol with the NMDA antagonists CNS-1102 and MK-801 but not with MgSO₄ produced treatment with strong synergistic effect that was at least as robust in reducing ischemic damage as caffeinol. This NMDA receptor antagonist and caffeine combination demonstrated a long window of opportunity, activity in spontaneously hypertensive rats, and, unlike caffeinol, was fully effective in animals chronically pretreated with ethanol.

Conclusions—Our study suggests that antiexcitotoxic properties may underlie some of the anti-ischemic effect of caffeinol. This study provides strong evidence that the anti-ischemic effect of NMDA receptor blockers in general can be dramatically augmented by caffeine, thus opening a possibility for new use of NMDA-based pharmacology in the treatment of stroke.