My botox shots did nothing to improve my arm use, because botox does nothing directly to fix the brain problem that causes spasticity.
Does Spasticity Reduction by Botulinum Toxin Type A Improve Upper Limb Functionality in Adult Post-Stroke Patients? A Systematic Review of Relevant Studies
2013, Journal of Neurology & Neurophysiology
Research ArticleOpen Access
Intiso et al., J Neurol Neurophysiol 2013, 4:4http://dx.doi.org/10.4172/2155-9562.1000167
Review ArticleOpen Access
Neurology & Neurophysiology
Volume 4 • Issue 4 • 1000167J Neurol NeurophysiolISSN: 2155-9562 JNN, an open access journal Stroke: Cerebrovascular Accident
Does Spasticity Reduction by Botulinum Toxin Type A Improve Upper Limb Functionality in Adult Post-Stroke Patients? A Systematic Review of Relevant Studies
Domenico Intiso
1
*, Valentina Simone
2
, Filomena Di Rienzo
1
, Andrea Santamato
3
, Mario Russo
1
, Maurizio Tolfa
1
, and Mario Basciani
1
1
Neuro-Rehabilitation Unit, Scientic Institute, Hospital ‘Casa Sollievo della Sofferenza’, Italy
2
Foundation rehabilitation “Gli Angeli di P.Pio”, San Giovanni Rotondo, Italy
3
Department of Physical Medicine and Rehabilitation, “OORR Hospital”, University of Foggia, Italy
*Corresponding author:
Domenico Intiso MD, Neuro-Rehabilitation Unit, Hospital
Scientic Institute “Casa Sollievo della Sofferenza”, Viale dei Cappuccini, 71013 San Giovanni Rotondo (FG), Italy, Tel: 039 882 410 942; Fax: 039 882 410 942; E-mail: d.intiso@operapadrepio.it
,
d.intiso@alice.it
Received
July 02, 2013;
Accepted
October
09, 2013;
Published
October
15
,
2013
Citation:
Intiso D, Simone
V, Rienzo FD
, Santamato A, Russo
M, et al.
(2013) J Neurol
Neurophysiol 4: 167. doi:10.4172/2155-9562.1000167
Copyright:
© 2013
Abstract
ObjectiveBotulinum toxin type A (BTX-A) use reduces upper limb (UL) spasticity in stroke patients, but the effects on functional recovery remain uncertain. The aim of present review was to ascertain if the reduction of spasticity by use of BTX-A was linked to a functional gain of UL or in activity of daily living in post-stroke patients.
Data source
: Search of relevant studies was conducted on MEDLINE, the Cochrane Central Register of Controlled Trials and EMBASE (1995 to July 2012).
Study selection
: Only randomized studies (RT) treating patients with UL post-stroke spasticity by BTX-A injection were included. Prospective open label, case series, cohort studies and case reports were excluded.
Data synthesis
: Thirty-four RTs were individuated, but only 16 were considered in the analysis. Trials varied widely in methodological design and measures used in assessing UL ability. Benet in UL functional recovery was reported in 13 studies, but only in six the result was signicant.
Conclusion
: some oriented-focused movements of UL unequivocally improve after reduced spasticity by BTX-A treatment, but evidence that arm functionality in adult post-stroke patients significantly benefit from this intervention is still doubt. No improvement in global functionality of activity daily living was observed.
Data source
: Search of relevant studies was conducted on MEDLINE, the Cochrane Central Register of Controlled Trials and EMBASE (1995 to July 2012).
Study selection
: Only randomized studies (RT) treating patients with UL post-stroke spasticity by BTX-A injection were included. Prospective open label, case series, cohort studies and case reports were excluded.
Data synthesis
: Thirty-four RTs were individuated, but only 16 were considered in the analysis. Trials varied widely in methodological design and measures used in assessing UL ability. Benet in UL functional recovery was reported in 13 studies, but only in six the result was signicant.
Conclusion
: some oriented-focused movements of UL unequivocally improve after reduced spasticity by BTX-A treatment, but evidence that arm functionality in adult post-stroke patients significantly benefit from this intervention is still doubt. No improvement in global functionality of activity daily living was observed.
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