I see NOTHING here that is going to help survivors recover. I blame the mentors and senior researchers for such useless research. They should be fired!
Evolution of Brain Activation with Good and Poor Motor Recovery after Stroke
Abstract
Objective.
To characterize the evolution of brain activation in stroke patients
with variable motor recovery and quantify changes relative to healthy
controls.
Methods.
Serial PET activation studies, using a simple
finger-tapping task, and quantitative measures of motor performance were
obtained in 9 patients (2-7 weeks poststroke and 6 months later) and
compared with serial healthy volunteer data.
Results.
Patients with
moderate impairment and good recovery (n = 5) activated the
primary sensorimotor cortex (SM1) contralateral to the paretic hand
moved, bilateral supplementary motor area (SMA), contralateral cingulate
gyrus, and ipsilateral lateral premotor cortex. Activation in the
bilateral SMA was greater at the initial study but reduced over time
compared to healthy controls and poor recoverers. Patients with severe
impairment and poor recovery (n =4) showed limited activation of
contralateral SM1 and SMA at both studies and no significant change over
time. A posterior shift in SM1 activation was evident in good and poor
recoverers.
Conclusions.
Activation of typical motor regions and
recruitment of additional sites occur subacutely poststroke, with
evolution to normal patterns in moderately impaired patients who recover
well. In comparison, severely impaired, poor-recovery patients show
persistent, reduced activation. Dynamic changes in SMA, differentially
observed in good recoverers over 6 months, highlight its importance in
recovery.
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