Deans' stroke musings: Alzheimer’s Symptoms Transferred via Microbiota Transplant

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, October 19, 2023

Alzheimer’s Symptoms Transferred via Microbiota Transplant

I can't tell if this includes fecal transplants or not. But beware.

Alzheimer’s Symptoms Transferred via Microbiota Transplant

Summary: A new study confirmed a link between gut microbiota and Alzheimer’s disease.

The research demonstrated that Alzheimer’s symptoms could be transferred to young, healthy organisms through gut microbiota transplants. Alzheimer’s patients exhibited a heightened presence of inflammation-causing bacteria, correlating with their cognitive state.

This discovery emphasizes the gut microbiome as a pivotal area of investigation for Alzheimer’s.

Key Facts:

Memory impairments in Alzheimer’s patients can be transferred to young animals via gut microbiota transplants.
Increased inflammation-promoting bacteria in the gut is directly connected to cognitive decline in Alzheimer’s patients.
The research suggests that early intervention by studying the role of gut microbes during the initial stages of dementia could lead to new therapeutic approaches.

Source: UCC

Researchers have discovered the link between the gut microbiota and Alzheimer’s disease.

For the first time, researchers have found that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, confirming its role in the disease.

The research was led by Professor Yvonne Nolan, APC Microbiome Ireland, a world leading SFI funded research centre based at University College Cork (UCC), and the Department of Anatomy and Neuroscience, UCC, with Professor Sandrine Thuret at King’s College London and Dr Annamaria Cattaneo IRCCS Fatebenefratelli, Italy.

The study supports the emergence of the gut microbiome as a key target for investigation in Alzheimer’s disease due to its particular susceptibility to lifestyle and environmental influences.

Published in Brain, the study shows that that the memory impairments in people with Alzheimer’s could be transferred to young animals through transplant of gut microbiota.

Alzheimer’s patients had a higher abundance of inflammation-promoting bacteria in faecal samples, and these changes were directly associated with their cognitive status.

Professor Yvonne Nolan said: “The memory tests we investigated rely on the growth of new nerve cells in the hippocampus region of the brain. We saw that animals with gut bacteria from people with Alzheimer’s produced fewer new nerve cells and had impaired memory.”

“People with Alzheimer’s are typically diagnosed at or after the onset of cognitive symptoms, which may be too late, at least for current therapeutic approaches. Understanding the role of gut microbes during prodromal – or early stage- dementia, before the potential onset of symptoms may open avenues for new therapy development, or even individualised intervention,” said Professor Nolan.

Alzheimer’s is the most common cause of dementia, a general term for memory loss and other cognitive abilities serious enough to interfere with daily life. As our population ages, one in three people born today are likely to develop Alzheimer’s.

Funded by Science Foundation Ireland, scientists in UCC are working to develop strategies to promote healthy brain ageing and advance treatments for Alzheimer’s by exploring how the gut microbiota respond to lifestyle influences like diet and exercise.

Professor Sandrine Thuret, Professor of Neuroscience at King’s College London and one of the study’s senior authors said, “Alzheimer’s is an insidious condition that there is yet no effective treatment for. This study represents an important step forward in our understanding of the disease, confirming that the make-up of our gut microbiota has a causal role in the development of the disease.

“This collaborative research has laid the groundwork for future research into this area, and my hope is that it will lead to potential advances in therapeutic interventions.”

The research was conducted by Dr Stefanie Grabrucker, a postdoctoral researcher working with Professor Nolan, in partnership with postdoctoral colleagues Dr Edina Silajdzic at King’s College London and Dr Moira Marizzoni, IRCCS Fatebenefratelli, Italy. UCC collaborators were Professor Cora O’Neill, Dr Olivia O’Leary, Dr Sarah Nicolas, Dr Jane English, Mr Sebastian Dohm-Hansen and Dr Aonghus Lavelle.

Professor. John F. Cryan, UCC Vice President for Research and Innovation, who was also involved in this research said: “I’m delighted to be involved in this exciting study that further enhances our understanding of the significant role played by the gut microbiome in brain related diseases, such as Alzheimer’s, and recognises UCC and APC Microbiome Ireland as leading institutions in microbiome and brain health research.

“This research aligns with our UCC Futures Framework and the strategic plan for the University in the areas of Food, Microbiome and Health and the soon to be launched Future Ageing and Brain Science.”