Deans' stroke musings: ASA: Alteplase Ups Outcomes at 4.5 to 24 Hours After Symptom Onset in Acute Ischemic Stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, February 20, 2025

ASA: Alteplase Ups Outcomes at 4.5 to 24 Hours After Symptom Onset in Acute Ischemic Stroke

According to survivor standards it was mostly a failure at 100% recovery. This just extends the failure window longer. But it met the tyranny of low expectations that your stroke medical 'professional' has. They will want 100% recovery when they are the 1 in 4 per WHO that has a stroke.

Schadenfreude will be a bitch for them knowing they could have solved stroke while still working!

ASA: Alteplase Ups Outcomes at 4.5 to 24 Hours After Symptom Onset in Acute Ischemic Stroke

TUESDAY, Feb. 18, 2025 (HealthDay News) — For patients with acute ischemic stroke (AIS) whose symptoms began 4.5 to 24 hours earlier, alteplase is associated with a higher percentage of patients achieving a score of 0 or 1 on the modified Rankin scale at 90 days, according to a study presented at the annual American Stroke Association International Stroke Conference, held from Feb. 5 to 7 in Los Angeles.

Min Lou, M.D., Ph.D., from the Second Affiliated Hospital of Zhejiang University School of Medicine in China, and colleagues conducted a prospective, randomized trial at 26 stroke centers in China involving patients with clinical signs of AIS within 4.5 and 24 hours and salvageable tissue on perfusion imaging. Patients were randomly assigned to receive intravenous alteplase or standard medical treatment (186 participants in both groups). The primary outcome was a score of 0 or 1 on the modified Rankin scale at 90 days.

Less than 3 percent of patients underwent endovascular thrombectomy (three and seven in the alteplase and standard medical treatment groups, respectively). The researchers found that the percentage of patients achieving a primary outcome was 40.3 and 26.3 percent in the alteplase and standard medical treatment groups, respectively (relative rate, 1.40; 95 percent confidence interval, 1.05 to 1.87). Mortality at 90 days was 10.8 percent with both alteplase and standard medical treatment, while the incidence of symptomatic intracerebral hemorrhage was 3.8 and 0.5 percent, respectively, within 36 hours after randomization.

“We believe these findings mean more people may return to normal or near-normal lives after a stroke, even if they receive treatment later than originally thought beneficial,” Lou said in a statement.

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