Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 31,822 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Friday, February 7, 2025
Repeated intermittent administration of 3,4-methylenedioxymethamphetamine mitigates demyelination in the brain from cuprizone-treated mice
Your competent? doctor has known of myelin problems from your stroke a long time ago, was anything done to solve it? NO? So, pure incompetence in action! A competent doctor would ensure human testing gets done to prevent demyelination post stroke.
3,4-Methylenedioxymethamphetamine
(MDMA), commonly known as a recreational drug, may also offer
therapeutic benefits for mental health. Population-based studies suggest
that MDMA users have a lower risk of demyelinating diseases, such as
depression. Given the role of the gut microbiota in mediating MDMA's
effects, we hypothesized that MDMA might confer mental health benefits
via the gut-brain axis. Cuprizone (CPZ) induces demyelination by
chelating copper, which leads to oligodendrocyte death and subsequent
myelin loss. This study investigated the impact of MDMA on brain
demyelination in CPZ-treated mice, focusing on the gut-brain axis.
Repeated intermittent MDMA administration (10 mg/kg, three times weekly
for 6 weeks) significantly reduced demyelination in the corpus callosum
(CC) of CPZ-treated mice. Gut microbiota and non-targeted metabolomics
analyses revealed notable differences in specific gut bacteria and
plasma (β-D-allose and L-sorbose) or fecal metabolite (carnitine) levels
between MDMA-treated and vehicle-treated CPZ-exposed mice. Negative
correlations were found between the levels of metabolites (β-D-allose,
L-sorbose, and carnitine) and the relative abundance of Romboutsia and Romboutsia timonensis.
These findings suggest that intermittent MDMA administration may
alleviate demyelination in the CC of CPZ-treated mice via the gut–brain
axis. Further research is needed to elucidate the roles of gut
microbiota and metabolites in MDMA's effects on brain demyelination and
to investigate other demyelination models.
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