Deans' stroke musings: Correlation of medial temporal lobe atrophy degree and brain connectivity on 3T MRI examination with cognitive function in post stroke patients

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, October 16, 2025

Correlation of medial temporal lobe atrophy degree and brain connectivity on 3T MRI examination with cognitive function in post stroke patients

The whole point of stroke research is RECOVERY! This completely fails that, you're fired!

Correlation of medial temporal lobe atrophy degree and brain connectivity on 3T MRI examination with cognitive function in post stroke patients

Saharuddin SAHARUDDIN 1 ✉, Bachtiar MURTALA 2, Junus A. BAAN 2, Andi A. ZAINUDDIN 3, Muhammad I. BASRI 4, Nikmatia LATIEF 2

1 Department of Radiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; 2 Department of Radiology, Faculty of Medicine, Dr. Wahidin Sudirohusodo Hospital, Hasanuddin University, Makassar, Indonesia; 3 Department of Public Health and Community Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; 4 Department of Neurology, Faculty of Medicine, Dr. Wahidin Sudirohusodo Hospital, Hasanuddin University, Makassar, Indonesia

BACKGROUND:

Cognitive impairment, affecting thinking, memory, and executive functions, can result from cerebrovascular diseases like stroke, leading to vascular cognitive impairment (VCI). The aim of this study was to correlate medial temporal lobe atrophy and brain connectivity on 3T MRI with cognitive function in post-stroke patients, using medial temporal lobe atrophy (MTA) score, diffusion tensor imaging (DTI-tractography), and Montreal Cognitive Assessment - Indonesian Version (MoCA-Ina) score.

METHODS:

This observational analytic study with a cross-sectional approach was conducted at our center from February to April 2024. The study population included all post-stroke patients who underwent head MRI examinations. We used for statistical analyses SPSS software v26.0 (IBM, Armonk, NY, USA). P values less than 0.05 were considered statistically significant.

RESULTS:

A total of 25 patients were included in this study. Patient characteristics were based on gender, age, education, stroke onset and stroke location. In this study, we found a significant correlation between education level, stroke onset, MTA score, fractional anisotropy (FA) values, and temporal stem (TS) tractography on MoCA-Ina score with P values of 0.016, 0.025, 0.002, 0.042, and 0.011, respectively. Additionally, there were also significant results showing correlation between MTA scores and FA scores on TS with P values of 0.002 and <0.001, respectively.

CONCLUSIONS:

There is a correlation between medial temporal lobe atrophy and brain connectivity with cognitive decline in post-stroke patients. Higher MTA scores are linked to lower FA values, leading to temporal stem fiber destruction and decreased cognitive function. Education background and stroke onset correlate with cognitive decline.