Study Finds Espresso May Help Protect Against Alzheimer's & Neurodegeneration

I'm not taking chances and do a 12 cup pot of coffee a day. 

How coffee protects against Parkinson’s Aug. 2014 

Coffee May Lower Your Risk of Dementia Feb. 2013

Coffee drinkers rejoice! Drinking coffee could lower the risk of Alzheimer’s disease 

And this: Coffee's Phenylindanes Fight Alzheimer's Plaque December 2018

New research suggests drinking coffee may reduce the risk of frailty May 2025

I think I'm in this category:  I never get the jitters or flushed skin.

Genetics determine how much coffee you can drink before it goes wrong

I'm doing a 12 cup pot of coffee a day with full fat milk to lessen my chances of dementia and Parkinsons. Tell me EXACTLY how much coffee to drink for that and I'll change. Yep, that is a lot more than the 400mg. suggested limit, I don't care! Preventing dementia and Parkinsons is vastly more important than whatever problems it can cause! 

Of course, your fuckingly incompetent? doctor did nothing with this from 2 years ago!

Dementia risk could drop by drinking just one shot daily of common beverage  August 2023

This line is great: The findings indicate that even the Espresso Martini cocktail contains the espresso's beneficial compounds - and can contribute to staving off dementia.

Will your competent? doctor and hospital ensure human testing gets done on this?

Study Finds Espresso May Help Protect Against Alzheimer's & Neurodegeneration

Most people drink espresso for the energy boost, others for the taste, and yes, even some for the health benefits. Previous research shows that beyond increasing alertness¹, black coffee can lower one's risk of coronary heart disease²protect the gut lining³, and boost metabolism⁴ And a preliminary study has discovered one more potential perk of your morning brew: It could help prevent neurodegenerative disease. Could espresso help protect against neurodegeneration? A study published in theJournal of Agricultural and Food Chemistry shows that in preliminary in vitro (read: not performed on humans) research, espresso compounds helped protect against Alzheimer’s disease and neurodegeneration⁵ The aggregation of tau protein in the brain is one mechanism that is suspected to contribute to the onset of Alzheimer’s. Tau protein isn’t inherently bad—everyone has it, and it actually helps stabilize structures in the brain. But when tau proteins begin aggregating and condensing, that's what researchers believe causes neurodegeneration to begin. Foor this study, researchers looked at how medium-roast ground coffee affected the behavior of tau protein in a cell model. Researchers pulled espresso shots (a blend of Arabica coffee from South America and Robusta coffee from Africa and Southwest Asia), taking note of their chemical makeup along the way. Then, they incubated these isolated molecules alongside tau protein for up to 40 hours. As the concentration of the compounds in the espresso shot increased, the shorter chains of tau protein did not form larger sheets (which would be indicative of Alzheimer’s). These shorter chains did not aggregate or act as “seeds,” as researchers describe it, for further aggregation. The greatest result happened when researchers used the full espresso extract versus the brew's isolated compounds. This means that espresso as a whole was more beneficial compared to the drink's isolated caffeine or other compounds.

Coffee vs. espresso

 Not sure what the differences are between the two? Head here This aligns with previous research that found that coffee could be potentially protective against cognitive decline⁶. However, it’s important to point out that the roasting process for espresso and coffee is different, so these results can’t necessarily be extrapolated to include regular coffee just yet, hence why more research is needed. As many coffee studies note, a modest amount of coffee or espresso intake (between two and three cups daily) is recommended, as caffeine overload can result in anxiety, high blood pressure, insomnia, and other unwanted side effects. Also, do your best to consume those cups at least eight hours before bed to prevent caffeine-induced insomnia. After all, sleep is one of the largest factors contributing to a healthy brain, so it's not worth interrupting or delaying. It’s safe to say that more research is needed to replicate these findings beyond in-vitro studies. Nevertheless, this is a launching point for more research on bioactive chemicals that could protect the brain from neurodegeneration and Alzheimer's. Plus, it's another confirmation that while coffee and espresso should be consumed in moderation, they can provide many benefits for brain health. Cheers to a brain- and energy-boosting latte—tryAn in-vitro study shows that espresso compounds could help prevent tau protein aggregation in the brain; a process that researchers believe contributes to the onset of neurodegeneration and Alzheimer’s.If you want to learn more about espresso’s benefits and how it compares to regular coffee, check out this primer.