Deans' stroke musings: Tobacco smoke diminishes neurogenesis and promotes gliogenesis in the dentate gyrus of adolescent rats

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, July 29, 2011

Tobacco smoke diminishes neurogenesis and promotes gliogenesis in the dentate gyrus of adolescent rats

Someday a researcher will put together all this stuff on nicotine into a stroke protocol. I know this says smoke reduces neurogenesis but from 2005 is nicotine promotes recovery.
http://oc1dean.blogspot.com/2010/10/nicotine-and-stroke-rehab.html
and is it just the smoke that causes problems?
http://www.sciencedirect.com/science/article/pii/S0006899311013473

Abstract

Brain disorders and environmental factors can affect neurogenesis and gliogenesis in the hippocampus. These studies investigated the effects of chronic exposure to tobacco smoke on progenitor cell proliferation and the survival and phenotype of new cells in the dentate gyrus of adolescent rats. The rats were exposed to tobacco smoke for 4 hrs per day for 14 days. To investigate cell proliferation, the exogenous marker 5-bromo-2'-deoxyuridine (BrdU, 200 mg/kg, ip) was administered 2 hrs into the 4-hr smoke exposure session on day 14. The rats were sacrificed 2–4 hrs after the administration of BrdU. To investigate cell survival, the same dose of BrdU was administered 24 hrs before the start of the 14-day smoke exposure period. These rats were sacrificed 24 hrs after the last smoke exposure session. Tobacco smoke exposure decreased both the number of dividing progenitor cells (− 19%) and the number of surviving new cells (− 20%), labeled with BrdU in the dentate gyrus. The decrease in cell proliferation was not associated with an increase in apoptotic cell death, as shown by TUNEL analysis. Colocalization studies indicated that exposure to tobacco smoke decreased the number of new immature neurons (BrdU/DCX-positive) and transition neurons (BrdU/DCX/NeuN-positive) and increased the number of new glial cells (BrdU/GFAP-positive). These findings demonstrate that exposure to tobacco smoke diminishes neurogenesis and promotes gliogenesis in the dentate gyrus of adolescent rats. These effects may play a role in the increased risk for depression and cognitive impairment in adolescent smokers.

Highlights

► Tobacco smoke inhibits cell proliferation in the dentate gyrus of adolescent rats ► Tobacco smoke inhibits cell survival in the dentate gyrus of adolescent rats ► Tobacco smoke inhibits neurogenesis in the dentate gyrus of adolescent rats ► Tobacco smoke promotes gliogenesis in the dentate gyrus of adolescent rats

From 2005