Deans' stroke musings: How Does A "Good" Protein Hurt Brain Cells After Clot-induced Stroke?

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, November 24, 2011

How Does A "Good" Protein Hurt Brain Cells After Clot-induced Stroke?

Finally some research on the hyperacute cascade of neuronal death. Much more needed. My editorial comment - We need to get away from this singular focus on tPA
http://www.medicalnewstoday.com/releases/238183.php
The National Institutes of Health has awarded a four-year, $1.4 million grant to Cedars-Sinai's Department of Neurology to study an unexpected recent discovery: After ischemic stroke the type caused by a clogged artery but with no bleeding into the brain a normal protein that plays a positive role in blood clotting escapes intact arteries and damages healthy brain cells.

"We knew thrombin leaked out during hemorrhagic strokes those in which an artery ruptures and we knew that in large amounts it killed brain cells. But we decided to see if there was thrombin after ischemic stroke, and, surprisingly, there was a lot, and it was causing major damage to brain cells. When we injected a drug that counters the effects of thrombin, stroke symptoms got better," said Patrick D. Lyden, MD, chair of the Department of Neurology and the Carmen and Louis Warschaw Chair in Neurology at Cedars-Sinai.

He was senior author of a 2010 article in the journal Stroke that described this phenomenon and suggested possible underlying mechanisms. The new grant, he said, will let researchers delve more deeply: Where is the thrombin coming from? What kinds of cells does it kill? What factors inhibit or enhance its effects?

Lyden will continue his work with Roger Y. Tsien, a scientist at the University of California, San Diego. He is one of three winners of the 2008 Nobel Prize in chemistry for development of green fluorescent protein.

Lyden's study will use fluorescence in rats and mice to light up thrombin and follow its migration and interactions with other molecules in blood vessels and brain tissue.

This is the first NIH funding directly awarded to the Department of Neurology, evidence of its growth since Lyden's arrival in 2009. He and other researchers are also supported by other NIH grants received before he joined Cedars-Sinai.