Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, November 9, 2011

Hair follicle stem cells – the hairy truth

So we may not have to use menstrual blood or fat cells to get our own stem cells. But what aboutLink me, mostly bald, would I have enough follicles to populate my missing 171 million neurons? Or do I have to go to my beard hair?
http://thenode.biologists.com/hair-follicle-stem-cells/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+the_Node+%28the+Node%29
Next time you curse your hair for your bad hair day, consider thanking it instead. The hair follicle has populations of stem cells that aid in skin regeneration after injury, and a recent Development paper unravels a new role for the transcription factor Lhx2 in this process.

Populations of epithelial stem cells in hair follicles serve to rebuild the hair bulb during the normal hair cycle throughout our lives, but they also can migrate to wounded skin in order to aid in skin regeneration. This ability is quite handy—when the skin in a hairy area is injured, it heals faster and more efficiently than a wound on skin without hair. Recently, a research group illuminated the importance of the transcription factor Lhx2 in the repair of injured skin by hair follicle stem cells. Lhx2 functions in organ development, cell fate determination, and stem cell activity in some organs. In hair follicles, Lhx2 was previously known to regulate the switch between stem cell maintenance and activity. In their recent report, Mardaryev and colleagues found that Lhx2+ hair follicle cells co-express several stem cell markers. Following injury, proliferating cells in the adjacent hair follicle were positive for Lhx2 expression, as seen in the images above. Lhx2 (magenta) expression increases by days 3 and 5 following injury. Most of the dividing cells (green) also are Lhx2+. In addition, cell proliferation following injury was reduced in heterozygous Lhx2 knockout (+/–) mice. Lhx2 ensures wound re-epithelization through its regulation of Sox9 and Tcf4, while at the same time inhibiting normal hair follicle cycling via Lgr5 regulation.
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