http://www.medpagetoday.com/Cardiology/PCI/31625
It appears to be safe for young women with new-generation aortic valves to maintain a low dose of warfarin therapy during pregnancy, a small pilot study found.
All 17 women who had a mechanical aortic valve and were on a regimen of 5 mg or less of warfarin a day delivered healthy babies by cesarean section, reported Luca S. De Santo, MD, from the University of Foggia in Naples, Italy, and colleagues.
Three women with bioprostheses (two mitral, one aortic) who were taking more than 5 mg of warfarin a day also delivered healthy babies, and at a mean of 59 months follow-up showed no signs of structural valve degeneration, researchers wrote in the March 20 issue of the Journal of the American College of Cardiology.
Despite the excellent results of this study, the researchers cautioned that the patients were highly selected and closely monitored.
They received extensive pre-pregnancy counseling regarding valve choice and anticoagulation therapeutic options.
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