http://www.sciencedirect.com/science/article/pii/S0306452212010780
Abstract
Neural
stem cells, which reside mainly in the subventricular and subgranular
zones of the hippocampus, can regenerate new neuroblasts after various
brain insults. Aided by vascular remodeling, these new neuroblasts
migrate long distances to injured brain regions. Studies have suggested
that high-mobility group box1 (HMGB1), a nonhistone nuclear DNA-binding
protein, may stimulate such remodeling in the late phase of some types
of brain injury, but it is unclear whether this is true for
intracerebral hemorrhage (ICH). Here we used a rat model of
collagenase-induced ICH to determine whether HMGB1 can promote
neurogenesis and angiogenesis in the late phase of injury. Daily
administration of ethyl pyruvate, which inhibited HMGB1 expression,
reduced recovery of neurological function, decreased VEGF and NGF levels
in the ipsilateral striatum, and decreased the numbers of BrdU- and
DCX-positive cells around the hematoma. These findings suggest that
HMGB1 may promote angiogenesis and neurogenesis in the late phase of
ICH.
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