Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, April 4, 2013

MULTIFACTORIAL MODULATION OF THE BLOOD-BRAIN BARRIER: RELATIONSHIP TO STROKE

No clue what this means. Ask your doctor to incorporate it into your stroke protocol. A great dissertation.
http://scholar.google.com/scholar_url?hl=en&q=http://uknowledge.uky.edu/cgi/viewcontent.cgi%3Farticle%3D1007%26context%3Dnutrisci_etds&sa=X&scisig=AAGBfm1eancpAqIHcifp9WcodG2cd6A3rg&oi=scholaralrt
The blood brain barrier (BBB) is a dynamic interface, mainly consisting of highly
specialized brain microvascular endothelial cells (BMECs) that segregate the
central nervous system (CNS) from the peripheral circulation. Impairment of the BBB, due to
disruption of tight junction (TJ) proteins and inflammatory responses, may initiate and/or
contribute to the progress of CNS disorders, including stroke. Stroke is the second
leading cause of death worldwide. It has been shown that aging and environmental
pollutants can induce brain endothelium dysfunction, and are considered as risk factors
for stroke.
Deficiency of telomerase is highly linked with aging associated vascular diseases.
Evidence indicates that patients with shorter telomere length are at higher risk of heart
disease or stroke. Results in this dissertation address the influence of telomerase reverse
transcriptase (TERT), a key component of telomerase, on the BBB integrity in
the context of ischemic stroke induced brain injury. Our results indicate that aging related
BBB alterations aggregate the stroke outcomes by inducing oxidative stress and
stimulating proinflammatory responses on the brain microvessels.
The ability of the BBB to protect the brain from harmful compounds indicates
that the BBB may be targeted by chemical toxicants in the peripheral circulation.
Polychlorinated biphenyls (PCBs) are persistent organic pollutants that
frequently bind to nanoparticles (NPs) in the environment
. Our results demonstrate that binding PCB153, one of the most abundant PCB congeners in the environment, to silica nanoparticles (PCB153 - NPs) potentiates
cerebrovascular toxicity and stroke outcomes via stimulation
of inflammatory responses and disruption of BBB integrity. These events are mediated by
activation of toll like receptor 4 (TLR4), which subsequently recruits tumor necrosis
factor associated factor 6 (TRAF6) and initiates the production of multiple inflammatory
mediators
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