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Clinical Cardiology, 05/30/2014 Review Article
Desai CK, et al. – The purpose of this study was to
review the currently available literature for vitamin supplementation
with respect to prevention of cardiovascular disease. They revealed
unfortunately, the current evidence suggests no benefit exists with
vitamin supplementation in the general US population. They also point
out that further research is needed to evaluate whether there are
specific populations that might benefit from vitamin supplementation.
- The production, sale, and consumption of multiple vitamins is a multibillion–dollar industry.
- Most Americans take some form of supplement ostensibly for prevention of cardiovascular disease.
- It has been claimed that vitamin A retards atherogenesis.
- Vitamin C is an antioxidant and is thought to possibly decrease free radical–induced endothelial injury, which can lead to atherosclerotic plaque formation.
- Vitamin E has been extensively studied for its possible effects on platelet function as well as inhibition of foam–cell formation.
- Low levels of vitamin D have been thought to negatively impact myocardial structure and increase the risk for cardiovascular events.
- Increased intake of vitamin B6, B12, and folate has been associated with reduction of homocysteine levels; elevated homocysteine blood levels have been associated with the occurrence of stroke, heart attack, and cardiovascular death.
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