Common Medicine Helps Repair Brain After Stroke, Study in Rats Suggests
If your doctor has any understanding of research and is willing to try something to save your neurons from dying.
http://aja.sagepub.com/content/29/5/401?etoc
- Steven Lehrer, MD1⇑
- Steven Lehrer, MD, Fermata Pharma, Inc, 30 West 60th Street, New York, New York 10023, USA. Email: steven@fermatapharma.com
Abstract
Alzheimer’s disease may result from
low-grade inflammation of the brain, and the characteristic amyloid β
may be a protective
response. Epidemiological observation indicates
that long-term oral administration of nonsteroidal anti-inflammatory
drugs
(NSAIDs) such as ibuprofen to patients having
rheumatoid arthritis results in reduced risk and delayed onset of
Alzheimer's
disease. However, oral ibuprofen, flurbiprofen, and
other NSAIDs are not an effective treatment. The NSAIDs may work as an
Alzheimer’s preventive but not a treatment because
the oral dose to the brain is too small, 1% to 2% of the total plasma
concentration.
The NSAID brain dose could be significantly
increased by delivering the drug intranasally. Flurbiprofen would be
preferable
to ibuprofen because flurbiprofen has 12½ times the
potency of ibuprofen. The smaller nasal dose of flurbiprofen than
ibuprofen
could significantly increase patient compliance.
Alzheimer’s disease starts in the entorhinal cortex, which is closely
connected
to the olfactory nerves, and spreads anatomically
in a defined pattern. Therefore, a nasal NSAID would readily reach the
region
of the brain where it is most likely to be
therapeutic.
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