http://www.nature.com/jcbfm/journal/vaop/ncurrent/full/jcbfm2014130a.html
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Abstract
This
review covers the pathogenesis of ischemic stroke and future directions
regarding therapeutic options after injury. Ischemic stroke is a
devastating disease process affecting millions of people worldwide every
year. The mechanisms underlying the pathophysiology of stroke are not
fully understood but there is increasing evidence demonstrating the
contribution of inflammation to the drastic changes after cerebral
ischemia. This inflammation not only immediately affects the infarcted
tissue but also causes long-term damage in the ischemic penumbra.
Furthermore, the interaction between inflammation and subsequent
neurogenesis is not well understood but the close relationship between
these two processes has garnered significant interest in the last decade
or so. Current approved therapy for stroke involving pharmacological
thrombolysis is limited in its efficacy and new treatment strategies
need to be investigated. Research aimed at new therapies is largely
about transplantation of neural stem cells and using endogenous
progenitor cells to promote brain repair. By understanding the
interaction between inflammation and neurogenesis, new potential
therapies could be developed to further establish brain repair
mechanisms.
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